[Current treatment status and future perspectives of advanced gallbladder cancer]

Abstract

Gallbladder cancer has an insidious onset,and most of the cases are in advanced stage at the time of diagnosis,with unfavorable prognosis. Radical surgery is the only potential curative method for gallbladder cancer at present,but radical surgery of advanced gallbladder cancer is difficult and the postoperative recurrence rate is high. Neoadjuvant therapy and conversion therapeutic modalities are of great significance to improve the rate of radical resection of advanced gallbladder cancer and reducing the risk of postoperative recurrence. The application and research of minimally invasive approach surgery in gallbladder cancer are increasing; organoid technology provides a new platform for precise and individualized treatment and new drug development, and the application of artificial intelligence combined with big data shows great potential in tumor diagnosis, surgical assistance and prognosis evaluation. Although these techniques provide more means to improve the therapeutic effect of advanced gallbladder cancer, there are still challenges in clinical practice and more high-quality clinical studies.