Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study

Ekaterina Zotcheva^{1

2}, Bjørn Heine Strand^{3

4

5}, Vegard Skirbekk^{3

5

6}, Kay Deckers⁷, Steinar Krokstad^{8

9}, Gill Livingston^{10

11}, Archana Singh-Manoux^{10

12}, Geir Selbæk^{3

4

13}

Affiliations

¹ Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway. ekaterina.zotcheva@aldringoghelse.no.
² Department of Geriatric Medicine, Oslo University Hospital, Nydalen, OUS HF, Ullevål Sykehus, PO Box 4956, 0424, Oslo, Norway. ekaterina.zotcheva@aldringoghelse.no.
³ Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway.
⁴ Department of Geriatric Medicine, Oslo University Hospital, Nydalen, OUS HF, Ullevål Sykehus, PO Box 4956, 0424, Oslo, Norway.
⁵ Department of Physical Health and Ageing, Norwegian Institute of Public Health, Skøyen, PO Box 222, 0213, Oslo, Norway.
⁶ Centre for Fertility and Health, Norwegian Institute of Public Health, PO Box 222, 0213, SkøyenOslo, Norway.
⁷ Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute (MHeNs), Alzheimer Centrum Limburg, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
⁸ Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology, PO Box 8905, 7491, Trondheim, Norway.
⁹ Levanger Hospital, Nord-Trøndelag Hospital Trust, PO Box 333, 7601, Levanger, Norway.
¹⁰ Division of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1 T7 NF, UK.
¹¹ North London NHS Foundation Trust, 4 St Pancras Way, London, NW1 OPE, UK.
¹² Epidemiology of Ageing and Neurodegenerative Diseases, U1153 Inserm, Université Paris Cité, 10 Avenue de Villemin, 75010, Paris, France.
¹³ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Blindern, PO Box 1072, 0316, Oslo, Norway.

PMID: 40259151
DOI: 10.1007/s11357-025-01660-3

Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study

Ekaterina Zotcheva et al. Geroscience. 2025.

. 2025 Apr 22.

doi: 10.1007/s11357-025-01660-3. Online ahead of print.

Authors

Affiliations

¹ Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway. ekaterina.zotcheva@aldringoghelse.no.
² Department of Geriatric Medicine, Oslo University Hospital, Nydalen, OUS HF, Ullevål Sykehus, PO Box 4956, 0424, Oslo, Norway. ekaterina.zotcheva@aldringoghelse.no.
³ Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway.
⁴ Department of Geriatric Medicine, Oslo University Hospital, Nydalen, OUS HF, Ullevål Sykehus, PO Box 4956, 0424, Oslo, Norway.
⁵ Department of Physical Health and Ageing, Norwegian Institute of Public Health, Skøyen, PO Box 222, 0213, Oslo, Norway.
⁶ Centre for Fertility and Health, Norwegian Institute of Public Health, PO Box 222, 0213, SkøyenOslo, Norway.
⁷ Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute (MHeNs), Alzheimer Centrum Limburg, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
⁸ Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology, PO Box 8905, 7491, Trondheim, Norway.
⁹ Levanger Hospital, Nord-Trøndelag Hospital Trust, PO Box 333, 7601, Levanger, Norway.
¹⁰ Division of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1 T7 NF, UK.
¹¹ North London NHS Foundation Trust, 4 St Pancras Way, London, NW1 OPE, UK.
¹² Epidemiology of Ageing and Neurodegenerative Diseases, U1153 Inserm, Université Paris Cité, 10 Avenue de Villemin, 75010, Paris, France.
¹³ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Blindern, PO Box 1072, 0316, Oslo, Norway.

PMID: 40259151
DOI: 10.1007/s11357-025-01660-3

Erratum in

Correction to: Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study.
Zotcheva E, Strand BH, Skirbekk V, Deckers K, Krokstad S, Livingston G, Singh-Manoux A, Selbæk G. Zotcheva E, et al. Geroscience. 2025 Jun 17. doi: 10.1007/s11357-025-01753-z. Online ahead of print. Geroscience. 2025. PMID: 40524031 No abstract available.

Abstract

We examined associations between body mass index (BMI), waist circumference (WC), and dementia risk, and differences in BMI and WC trajectories before dementia diagnosis. We included 9,739 participants (54% women) aged 70+ from the Trøndelag Health Study (HUNT4 70+). BMI was measured four times (1984-2019) and WC three times (1995-2019). Dementia diagnoses were clinically assessed at HUNT4 70+ . Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.

Keywords: Adiposity; Anthropometric measures; Cognitive impairment; Life-course perspective; Population-based study.

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Conflict of interest statement

Declarations. Conflicts of interest: EZ, BHS, VS, KD, SK, GL and ASM declare no conflicts of interest. GS has participated in Advisory Board meetings for Roche, Eli-Lilly and Eisai regarding disease-modifying drugs for Alzheimer’s disease. GS has received honoraria for delivering lectures at symposia sponsored by Eisai and Eli-Lilly.

References

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Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study

Affiliations

Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

References

Grants and funding

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