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Review
. 2025 Apr 7:16:1524711.
doi: 10.3389/fimmu.2025.1524711. eCollection 2025.

Ferroptosis: a novel perspective on tumor immunotherapy

Yuan Xu  1 , Mingpai Ge  1 , Yuqing Xu  1 , Kai Yin  1
Affiliations
Review

Ferroptosis: a novel perspective on tumor immunotherapy

Yuan Xu et al. Front Immunol. .

Abstract

Ferroptosis is a novel form of programmed cell death characterized by iron-dependent accumulation of reactive oxygen species (ROS) and lipid peroxidation. The execution of ferroptosis is intricately linked to both iron and lipid metabolism. Intriguingly, iron and lipid metabolism are also pivotal for maintaining the physiological function of immune cells. Research has revealed that ferroptosis can potentiate the immunogenicity of tumor cells and engage in intricate interactions with immune cells. Certain ferroptosis inducers have the capacity to augment the efficacy of immunotherapy by modulating the tumor immune microenvironment. Ferroptosis holds immense potential in cancer immunotherapy and is anticipated to emerge as a novel therapeutic target in the future landscape of cancer treatment. In this review, we primarily delineate the ferroptosis signaling pathways and metabolic processes pertinent to immune cells, and further summarize the roles of ferroptosis in tumor-infiltrating immune cells. Ultimately, we anticipate further elucidation of the mechanisms of ferroptosis in immunotherapy and envision that strategies targeting ferroptosis and immunotherapy will be expeditiously applied in clinical oncology practice.

Keywords: ferroptosis; immune cell; immunotherapy; metabolism; tumor immunotherapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Signaling pathways in ferroptosis.
See this image and copyright information in PMC

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