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Review
. 2025 Apr 23;22(1):30.
doi: 10.1007/s11904-025-00739-y.

Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission

Dvora Joseph Davey  1   2 , Alex de Voux  3 , Natalie Shaetonhodi  3 , Michael Marks  4 , Lisa Frigati  5 , Tendesayi Kufa  6   7
Affiliations
Review

Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission

Dvora Joseph Davey et al. Curr HIV/AIDS Rep. .

Abstract

Background: There is an urgent need to improve interventions for HIV and syphilis in pregnancy to achieve elimination.

Results: The tenets of vertical transmission strategies for HIV and syphilis overlap but have varying success due to differences in their transmission dynamics, diagnoses, and treatment. Key principles include prevention of maternal infection, screening and diagnosis early and throughout antenatal care, curative treatment (syphilis), viral load suppression (HIV), early infant diagnosis and treatment (HIV and congenital syphilis). We recommend improved guidelines, provider training and focused research and surveillance, including implementation studies to align HIV and syphilis screening and treatment during pregnancy. Opportunities to integrate syphilis screening and treatment into antenatal and HIV care enable providers to offer comprehensive maternal care.

Conclusion: Integrated HIV/syphilis services ensure a cohesive and person-centered approach, improving health outcomes through streamlined, efficient, and family-centered care pathways. We recommend key interventions to reduce HIV and syphilis in pregnancy and prevent vertical transmission.

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Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Overlap of HIV and syphilis services delivery and opportunities for improved integration for pregnant women and infants
See this image and copyright information in PMC

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References

    1. World Health Organization. HIV – Estimated percentage of pregnant women living with HIV who received antiretrovirals for preventing mother-to-child transmission. Global Health Observatory. 2024. Accessed September 11, 2024. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/estim...
    1. UNICEF. Progress in reducing new HIV infections among children has stagnated in recent years. Elimination of mother-to-child transmission. 2024. Accessed October 31, 2024. https://data.unicef.org/topic/hivaids/emtct/
    1. World Health Organization. Investment case for eliminating mother-to-child transmission of syphilis: Promoting better maternal and child health and stronger health systems. Published online 2012
    1. World Health Organization. Strategic Information. Global Sexually Transmitted Infections Programme. 2024. Accessed October 31, 2024. https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/stis/...
    1. Graybill LA, Kasaro M, Freeborn K, et al. Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2020;34(5):761. 10.1097/QAD.0000000000002487. - PMC - PubMed

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