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Review
. 2025 Apr 22.
doi: 10.1007/s11764-025-01812-6. Online ahead of print.

Fear of cancer recurrence among adolescent and young adult cancer survivors: a mixed-methods systematic review

Ziyi Chen  1 , Ping Ni  2 , Bei Wu  3 , Eunjeong Ko  4 , Jing Liao  5 , Huijing Lin  6 , Peiying Ma  1
Affiliations
Review

Fear of cancer recurrence among adolescent and young adult cancer survivors: a mixed-methods systematic review

Ziyi Chen et al. J Cancer Surviv. .

Abstract

Purpose: Fear of cancer recurrence (FCR) is common and burdensome in adolescent and young adult (AYA) cancer survivors. This systematic review examines FCR assessment, prevalence, severity, progression, related factors, consequences, and interventions in AYA cancer survivors.

Methods: Electronic databases including PubMed, CINAHL, PsycINFO, Cochrane, and Embase were searched from their inception to October 2024. Two reviewers identified eligible peer-reviewed empirical studies, including both qualitative and quantitative ones on FCR in AYA survivors. The risk of bias was assessed using the Mixed-Methods Appraisal Tool. Quantitative studies were synthesized narratively, while qualitative studies underwent thematic synthesis.

Results: Among the 5340 studies identified, 34 studies were included finally. 21.4 to 93.3% of AYA cancer survivors experienced FCR. About one-third of survivors with moderate or high FCR improved over time. Female survivors, those with advanced cancer stages, and individuals with negative illness perceptions or higher anxiety reported higher FCR. Persistent FCR was associated with increased psychological problems and lower quality of life. Two studies on behavioral interventions, particularly internet-based cognitive-behavioral therapy (CBT), were acceptable but had limited evidence of efficacy.

Conclusion: FCR is prevalent among AYA cancer survivors, particularly in female survivors, those with advanced cancer stages, and those with negative perceptions or higher anxiety. A significant proportion experience persistent, but variability in current evidence limits a comprehensive understanding of its severity, progression, and intervention efficacy. To enhance FCR management, the use of validated assessment tools is essential in both research and clinical contexts. Addressing the physical and psychological aspects of survivorship through comprehensive care is crucial for alleviating FCR and improving overall well-being.

Implications for cancer survivors: Identifying the key factors of FCR will stimulate the research and the development of targeted interventions for AYA cancer survivors.

Keywords: Adolescent; Cancer Survivors; Fear of Cancer Recurrence; Oncology; Systematic review; Young Adult.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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