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. 2025 Jan-Mar;17(1):4-10.
doi: 10.32607/actanaturae.27547.

Pro-inflammatory Cytokines, Ferroptosis, and Cancer

A A Vartanian  1 , V S Kosorukov  1
Affiliations

Pro-inflammatory Cytokines, Ferroptosis, and Cancer

A A Vartanian et al. Acta Naturae. 2025 Jan-Mar.

Abstract

Ferroptosis, iron-dependent regulated cell death, is induced by the polyunsaturated fatty acid peroxidation of membrane phospholipids and is controlled by glutathione peroxidase 4. In recent years, convincing evidence has emerged, demonstrating a close relationship between chemo-, radio-, immuno-, and targeted therapy resistance and ferroptosis resistance. In this review, we discuss the basic principles of ferroptosis in cancer. Considerable attention is paid to the formation of an immunosuppressive tumor microenvironment. The main focus is centered on the involvement of the excessive, chronic production of pro-inflammatory cytokines in ferroptosis resistance development in tumors.

Keywords: cancer; ferroptosis; intratumoral immunosuppression; pro-inflamatory cytokines.

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