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. 2025 Apr 21;13(4):e70456.
doi: 10.1002/ccr3.70456. eCollection 2025 Apr.

Manifestation of "Wing-Beating" Tremors Along With Appearance of the "Giant Panda" Sign on Brain MRI in Neuro Wilson's Disease Due to Treatment Failure: A Case Report

Rupal Vikas Dosi  1 , Kush Pankaj Shah  1 , Jeel Narendra Sarvaiya  2 , Dakshi Jignesh Kadakia  1 , Dax Rajendra Patel  1 , Aarushi Mishra  3
Affiliations

Manifestation of "Wing-Beating" Tremors Along With Appearance of the "Giant Panda" Sign on Brain MRI in Neuro Wilson's Disease Due to Treatment Failure: A Case Report

Rupal Vikas Dosi et al. Clin Case Rep. .

Abstract

We report a patient of neuro Wilson's disease who presented with "wing-beating" tremors and "giant panda" sign on magnetic resonance imaging, 1 year after initiation of treatment with zinc acetate. We focus on the importance of initiating copper chelator therapy as the first line treatment as it improves the prognosis and prevents irreversible complications.

Keywords: Kayser–Fleischer ring; Wilson's disease; d‐penicillinamine; giant panda sign; wing‐beating tremor; zinc acetate.

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Conflict of interest statement

Permission from all authors has been obtained for publication of final version of this manuscript. All authors have agreed to be accountable and responsible for all aspects of this work.The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Kayser–Fleischer ring in descement layer of cornea.
FIGURE 2
FIGURE 2
“Giant panda” sign is noted in the midbrain on MRI.
See this image and copyright information in PMC

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