Funding Support and Author Disclosures The study was founded by Copenhagen University Hospital - Herlev and Gentofte, Gangstedfonden, and was supported by a research grant from the Danish Cardiovascular Academy (Grant number 2022007-HF), which is funded by the Novo Nordisk Foundation, grant number NNF20SA0067242 and The Danish Heart Foundation. The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the paper. This study was performed using the UK Biobank under Application Number 104807. Dr Thomas has received lecture honoraria from Amgen and Novo Nordisk. Prof Kamstrup has received lecture honoraria or consultancies from Physicians’ Academy for Cardiovascular Education, PCSK9 Forum, Medscape, Silence Therapeutics, Novartis, Amgen, and Eli Lilly. Prof Nordestgaard has received lecture honoraria or consultancies from Abbott, Akcea, Amarin, Amgen, Arrowhead, AstraZeneca, Denka, Esperion, Kowa, Eli Lilly, Mankind, Marea Therapeutics, Novartis, Novo Nordisk, Regeneron, Sanofi, Silence Therapeutics, and Ultragenyx. Dr Vedel-Krogh has reported that she has no relationships relevant to the contents of this paper to disclose.