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. 1977 Jan 31;51(2):189-93.
doi: 10.1007/BF00431739.

Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin

R J Katz, B J Carroll
Free article

Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin

R J Katz et al. Psychopharmacology (Berl). .
Free article

Abstract

The 5-hydroxytryptamine (5-HT, serotonin) specific presynaptic reuptake inhibitor Lilly 110140 (fluoxetine hydroxhloride) was injected systemically in rats trained to bar-press for rewarding stimulation to the caudal portion of the medial forebrain bundle. Rates of self stimulation were reduced in proportion to drug dosage, and these reductions were partially reversible by methysergide. These findings are consistent with previous reports suggesting an inhibitory role for 5-HT in self stimulation.

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