Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jan 31;51(2):189-93.
doi: 10.1007/BF00431739.

Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin

R J Katz, B J Carroll
Free article

Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin

R J Katz et al. Psychopharmacology (Berl). .
Free article

Abstract

The 5-hydroxytryptamine (5-HT, serotonin) specific presynaptic reuptake inhibitor Lilly 110140 (fluoxetine hydroxhloride) was injected systemically in rats trained to bar-press for rewarding stimulation to the caudal portion of the medial forebrain bundle. Rates of self stimulation were reduced in proportion to drug dosage, and these reductions were partially reversible by methysergide. These findings are consistent with previous reports suggesting an inhibitory role for 5-HT in self stimulation.

PubMed Disclaimer

References

    1. Eur J Pharmacol. 1974 Sep;28(1):233-6 - PubMed
    1. Pharmacol Biochem Behav. 1976 Apr;4(4):477-9 - PubMed
    1. Life Sci. 1974 Sep 15;15(6):1161-71 - PubMed
    1. J Neural Transm. 1974;35(4):157-273 - PubMed
    1. Science. 1970 Jun 12;168(3937):1370-2 - PubMed

Publication types

LinkOut - more resources