A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys
- PMID: 402685
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A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys
Res Commun Chem Pathol Pharmacol.
1977 Jan.
Abstract
(-)-9-Nor-9beta-hydroxy-hexahydrocannabinol[(-)-9-nor-9beta-OH-HHC] produced hypotension and bradycardia in anesthetized dogs, was a potent antinociceptive agent in the mouse tail-flick and p-phenylquinone abdominal-stretching tests, but did not reverse the effects of morphine withdrawal in dependent monkeys.
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