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. 1977 Jan;16(1):187-90.

A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys

B R Martin, W L Dewey, M D Aceto, M D Adams, J T Earnhardt, J M Carney
  • PMID: 402685

A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys

B R Martin et al. Res Commun Chem Pathol Pharmacol. 1977 Jan.

Abstract

(-)-9-Nor-9beta-hydroxy-hexahydrocannabinol[(-)-9-nor-9beta-OH-HHC] produced hypotension and bradycardia in anesthetized dogs, was a potent antinociceptive agent in the mouse tail-flick and p-phenylquinone abdominal-stretching tests, but did not reverse the effects of morphine withdrawal in dependent monkeys.

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