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Case Reports
. 2025 Apr 23;25(1):193.
doi: 10.1186/s12890-025-03666-1.

A case report of hemothorax due to intrathoracic variceal rupture linked to Budd-Chiari syndrome

Affiliations
Case Reports

A case report of hemothorax due to intrathoracic variceal rupture linked to Budd-Chiari syndrome

Yue Hu et al. BMC Pulm Med. .

Abstract

Background: Budd-Chiari syndrome (BCS) is a hepatic venous system disease caused by obstruction of the hepatic blood flow outflow tract. The definition of hemothorax is that blood accumulates in the chest cavity, and the hematocrit value of the effusion exceeds 50%. Hemothorax caused by intrathoracic variceal rupture associated with BCS is rare.

Case presentation: A 43-year-old female patient with just 69 g/L hemoglobin, complaining of shortness of breath for 2 days, was admitted to gastroenterology department. The chest computed tomography (CT) revealed right pleural effusion and contrast-enhanced CT in portal venous phase revealed portal hypertension and multiple tortuous veins. The ratio of red blood cells to white blood cells in bloody pleural effusion was about 500:1, and the neuron-specific enolase (NSE) and cytokeratin 19 fragment antigen 21 - 1 (CYFRA21-1) in the pleural effusion were significantly increased. Therefore, the patient was transferred to the respiratory medicine department to exclude malignant pleural effusion. The enhanced chest CT reexamination showed a continuous enhanced soft tissue-like lump in the thoracic cavity, which was a varicose vein. The vascular interventional physician reviewed the contrast-enhanced CT in portal venous phase to see a stenosis between the hepatic vein and the inferior vena cava, so BCS was suspected. Vascular interventional surgery was performed, and identified obstructed blood flow at the upper end of the inferior vena cava, which significantly improved after thrombolysis. Therefore, the intrathoracic variceal rupture linked to BCS was the source of the patient's pleural effusion.

Conclusions: when there is unexplained bloody pleural effusion and the tumor index of pleural effusion increases, thoracoscopic pleural biopsy should not be blindly performed, and pleural effusion caused by vascular rupture should be further excluded.

Keywords: Budd-Chiari syndrome; Hemothorax; Intrathoracic variceal rupture.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The patient was treated ethically in accordance with the declaration of Helsinki. The patient has signed written informed consent for publication of this case report and all the accompanying images. Consent for publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable.

Figures

Fig. 1
Fig. 1
Chest computed tomography (CT). (a) Right pleural effusion and lung atelectasis; (b) subcutaneous varicose vein of the abdominal wall (white arrow); (c) Cirrhosis and splenomegaly
Fig. 2
Fig. 2
Contrast-enhanced CT in portal venous phase. (a) Dilated abdominal wall vein; (b) Dilated splenic veins (white arrow), splenomegaly, cirrhosis and portal hypertension; (c) Dilated paravertebral vein and communicated with the left renal vein (white arrow)
Fig. 3
Fig. 3
Thoracic ultrasound. Right pleural effusion, up and down by 126 mm, anteroposterior diameter of 103 mm, and floating the lung tissue
Fig. 4
Fig. 4
Enhanced chest CT. (a and b) A continuous enhanced soft tissue-like lump in the posterior mediastinum, which was a varicose vein (white arrow)
Fig. 5
Fig. 5
Contrast-enhanced CT in portal venous phase: sagittal (a) and coronal (b) view. A stenosis (white arrow) between the hepatic vein and the inferior vena cava
Fig. 6
Fig. 6
Vascular interventional surgery. (a) The blood flow at the upper end of the inferior vena cava was blocked. (b) The blood flow in the inferior vena cava occlusion segment was significantly improved after 200,000 U of urokinase thrombolysis
Fig. 7
Fig. 7
Two months after vascular interventional surgery, re-examination of the enhanced upper abdominal CT revealed significant reduction of the intrathoracic varicose vein (white arrow)

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