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. 2025 Apr 12;12(4):ofaf227.
doi: 10.1093/ofid/ofaf227. eCollection 2025 Apr.

Different Clinical Severity and Outcomes in a Cohort of Patients With Dengue With Warning Signs in an Endemic Latin American City

Mara Gómez-Zambrano  1 , Daniela Torres-Hernández  1 , Monica A Murillo-Ortiz  2   3 , Isabel C Hurtado  2   4 , Diana M Dávalos  5 , Erika Cantor  6 , Pio López  1   5 , Nathan D Grubaugh  7   8   9 , Eduardo López-Medina  1   5   10
Affiliations

Different Clinical Severity and Outcomes in a Cohort of Patients With Dengue With Warning Signs in an Endemic Latin American City

Mara Gómez-Zambrano et al. Open Forum Infect Dis. .

Abstract

We used a detailed dengue classification to assess the variability in disease severity and outcomes in a cohort of patients classified as "dengue with warning signs" according to the 2009 World Health Organization (WHO) criteria. We describe a wide range of severity and outcomes, which highlights the need and potential to improve the current WHO dengue classification.

Keywords: classification; dengue; outcomes; severity; warning signs.

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Conflict of interest statement

Potential conflicts of interest. E. L.-M. has received research funding and advisory fees from Takeda; all unrelated to the present study. All other authors report no potential conflicts.

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