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Meta-Analysis
. 2025 Jun;35(6):2321-2332.
doi: 10.1007/s11695-025-07865-x. Epub 2025 Apr 24.

Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis

Narek Sargsyan  1 , Iihan Ali  2 , Christopher Namgoong  2 , Bibek Das  1   3 , Matyas Fehervari #  1   4 , Michael G Fadel #  5   6
Affiliations
Meta-Analysis

Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis

Narek Sargsyan et al. Obes Surg. 2025 Jun.

Abstract

We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD) in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies that reported on GORD outcomes following RYGB for obesity (January 2000-November 2023). Fourteen studies with 28,027 patients underwent RYGB, with pooled analysis demonstrating a 47% (95% CI 34.0-59.0; p ≤ 0.005) improvement in GORD symptoms and 4.5% (95% CI 1.7-7.2; p ≤ 0.005) with worsening/new onset GORD. Postoperative DeMeester score improved by 16.49 points (95% CI 0.2-32.7; p ≤ 0.005) and 79.4% (95% CI 68.7-90.1; p = 0.01) completely discontinued proton-pump inhibitor therapy during the follow-up period. RYGB surgery may potentially improve GORD symptoms in patients with obesity, with an overall low incidence of de novo GORD.

Keywords: Bariatric surgery; Gastric bypass; Gastro-oesophageal reflux disease; Obesity; Outcomes.

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Conflict of interest statement

Declarations. Ethics Approval: For this type of study, systematic review and analysis, formal consent is not required. Competing Interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The flowchart shows the literature search and study selection process according to the PRISMA guidelines
Fig. 2
Fig. 2
Forest plot demonstrating A improvement of GORD symptoms, B no improvement of GORD symptoms, and C new or worsening GORD symptoms following Roux-en-Y gastric bypass
Fig. 3
Fig. 3
Forest plot demonstrating A discontinuation of proton-pump inhibitors following Roux-en-Y gastric bypass and B preoperative versus postoperative DeMeester score
Fig. 4
Fig. 4
Forest plot demonstrating A length of stay and B changes in BMI following Roux-en-Y gastric bypass
See this image and copyright information in PMC

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