Mesenchymal stem cells in hematology: Therapeutic initiatives and future directions

Abstract

In recent years, the landscape of hematology has undergone rapid transformation, driven by innovative therapeutic strategies harnessing the properties of novel cellular therapies. Mesenchymal stem cells (MSCs) represent one of these promising therapies, with potential applications across a range of hematologic conditions. These cells are notable for their immunomodulatory properties, key role in supporting the hematopoietic micro-environment and capacity for multi-directional differentiation. This review will focus on the biologic mechanisms underlying MSC therapeutic use, current avenues of clinical investigation, and potential challenges and future directions for MSC derived therapies.

Keywords: Cell therapy; Graft-versus-host disease; Hematopoietic stem cell transplantation; Immune thrombocytopenic purpura; Mesenchymal stem cells.