Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jun;85(2):387-93.
doi: 10.1111/j.1476-5381.1985.tb08873.x.

The effect of diltiazem on noradrenaline release

C Wolchinsky, T T Zsotér

The effect of diltiazem on noradrenaline release

C Wolchinsky et al. Br J Pharmacol. 1985 Jun.

Abstract

The effects of diltiazem in rat tail arteries and guinea-pig vasa deferentia have been investigated. Superfusion of the rat tail artery with diltiazem (10(-6) - 10(-4) M) resulted in a dose-related increase in 3H-overflow (P less than 0.001) both in Wistar Kyoto (WKY) and in spontaneously hypertensive (SHR) rats. Release of 3H by transmural stimulation (1 Hz, 2 ms, 10 V) was also much greater in vessels perfused with diltiazem; this effect was dose-dependent. Diltiazem did not significantly alter the proportion of noradrenaline and its metabolites in 3H-overflow, as analysed by column chromatography. In the vasa deferentia of guinea-pigs, diltiazem (10(-9) - 10(-5) M) increased spontaneous 3H-release. The results indicate that diltiazem acts on sympathetic nerves and causes the release of noradrenaline.

PubMed Disclaimer

References

    1. Experientia. 1967 Nov 15;23(11):933-4 - PubMed
    1. Jpn Circ J. 1963 Mar;27:282-93 - PubMed
    1. Cardiovasc Res. 1972 Mar;6(2):120-8 - PubMed
    1. Arzneimittelforschung. 1973 Feb;23(2):193-7 - PubMed
    1. Biochem Pharmacol. 1973 May 15;22(10):1147-60 - PubMed

Publication types

LinkOut - more resources