Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy

Bo-Xi Liu¹, Syed Anis Ali Shah¹, Feng Zhou¹, Weidong Rao², Shu-Su Shen³, Daopeng Sheng⁴, Shun-Yi Wang¹

Affiliations

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
² Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
³ School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, P. R. China.
⁴ State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.

PMID: 40275645
DOI: 10.1021/acs.orglett.5c00899

Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy

Bo-Xi Liu et al. Org Lett. 2025.

. 2025 May 9;27(18):4656-4662.

doi: 10.1021/acs.orglett.5c00899. Epub 2025 Apr 24.

Authors

Bo-Xi Liu¹, Syed Anis Ali Shah¹, Feng Zhou¹, Weidong Rao², Shu-Su Shen³, Daopeng Sheng⁴, Shun-Yi Wang¹

Affiliations

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
² Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
³ School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, P. R. China.
⁴ State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.

PMID: 40275645
DOI: 10.1021/acs.orglett.5c00899

Abstract

A visible-light-induced trifunctionalization of unactivated alkenes for building functionalized oxindoles through a radical cyano migration strategy is reported. This transformation employs a tandem alkene sulfonylation-initiated cyano migration/cyclization cascade process. This strategy features stable and easily accessible substrates, mild reaction conditions, metal-free catalysts, and the capability of late-stage functionalization.

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Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy

Affiliations

Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy

Authors

Affiliations

Abstract

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Full Text Sources