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Review
. 2025 Apr 14;29(6):298.
doi: 10.3892/ol.2025.15044. eCollection 2025 Jun.

Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)

Hui Hu  1 , Wen-Jun Chen  2 , Chuang Sun  3 , Jun-Ping Xie  1
Affiliations
Review

Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review)

Hui Hu et al. Oncol Lett. .

Abstract

Lung cancer is a major global health concern in terms of both incidence and mortality. Despite substantial advancements in targeted therapy and immune checkpoint inhibitor treatments, their overall effectiveness is limited. Dendritic cells (DCs) are crucial in innate and acquired immune responses due to their effective presentation of antigens. DC-based cancer vaccines have been identified as promising strategies for personalized cancer immunotherapy. The present review presents a thorough examination of the immunomodulation and associated mechanisms of DC vaccines in lung cancer, with a specific emphasis on the presentation of clinical trial data concerning the safety, feasibility and effectiveness of DC vaccines in the treatment of patients with lung cancer. The objective of this review is to highlight strategies and provide insights that may improve the development and clinical efficacy of DC vaccines for the treatment lung cancer.

Keywords: dendritic cell vaccine; dendritic cells; lung cancer.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

    1. Bray F, Laversanne M, Sung H, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–263. doi: 10.3322/caac.21834. - DOI - PubMed
    1. Oliveira G, Wu CJ. Dynamics and specificities of T cells in cancer immunotherapy. Nat Rev Cancer. 2023;23:295–316. doi: 10.1038/s41568-023-00560-y. - DOI - PMC - PubMed
    1. Qian D, Li J, Huang M, Cui Q, Liu X, Sun K. Dendritic cell vaccines in breast cancer: Immune modulation and immunotherapy. Biomed Pharmacother. 2023;162:114685. doi: 10.1016/j.biopha.2023.114685. - DOI - PubMed
    1. Moore ZS, Seward JF, Lane JM. Smallpox. Lancet. 2006;367:425–435. doi: 10.1016/S0140-6736(06)68143-9. - DOI - PubMed
    1. Zhang M, Wang Y, Chen X, Zhang F, Chen J, Zhu H, Li J, Chen Z, Wang A, Xiao Y, et al. DC vaccine enhances CAR-T cell antitumor activity by overcoming T cell exhaustion and promoting T cell infiltration in solid tumors. Clin Transl Oncol. 2023;25:2972–2982. doi: 10.1007/s12094-023-03161-1. - DOI - PubMed

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