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. 2025 Apr 22;24(1):106.
doi: 10.1007/s40200-025-01619-3. eCollection 2025 Jun.

MiR-568-5p, the key regulator of suppressor of cytokine signaling 4 (SOCS4) in the coronary artery disease

Tayebeh Sadeghi  1 , Majid Zaki-Dizaji  2 , Meisam Rostaminasab Dolatabad  3 , Zahra Taheri  4
Affiliations

MiR-568-5p, the key regulator of suppressor of cytokine signaling 4 (SOCS4) in the coronary artery disease

Tayebeh Sadeghi et al. J Diabetes Metab Disord. .

Abstract

Objectives: Pro-inflammatory molecules are key risk factors for coronary artery diseases (CAD). Therefore, the regulation of inflammatory responses plays a crucial role in CAD. Suppressor of cytokine signaling 4 (SOCS4) is a negative regulator of cytokine signaling may significantly contribute to the pathogenesis of CAD. Bioinformatics studies indicate that hsa-miR-568-5p can target SOCS4. This study aimed to evaluate the expression of hsa-miR-568-5p in patients with CAD and investigate its correlation with SOCS4 levels.

Methods: The study included 20 Iranian participants without artery stenosis and 40 with artery stenosis. The relative expression levels of hsa-miR-568-5p and SOCS4 were assessed using Real-Time PCR.

Results: The findings revealed no significant difference in the expression levels of hsa-miR-568-5p and SOCS4 between the two groups. Also, correlations were not observed between hsa-miR-568-5p, SOCS4, and age in both the control and CAD patient groups.

Conclusions: While hsa-miR-568-5p regulates SOCS4 expression, and SOCS4 upregulation is implicated in coronary artery disease (CAD) protection, this study found no conclusive evidence supporting this relationship. Further research is warranted.

Keywords: Coronary artery diseases; Hsa-miR-568-5p; MicroRNA; Suppressor of cytokine signaling 4.

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Conflict of interest statement

Conflict of interestThe authors declare no conflict of interest.

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