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. 2025 Apr 14;36(2):102531.
doi: 10.1016/j.omtn.2025.102531. eCollection 2025 Jun 10.

We ARE boosting translation: AU-rich elements for enhanced therapeutic mRNA translation

Guendalina Froechlich  1   2 , Emanuele Sasso  1   2   3
Affiliations

We ARE boosting translation: AU-rich elements for enhanced therapeutic mRNA translation

Guendalina Froechlich et al. Mol Ther Nucleic Acids. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Iconographic description of AU-rich element (ARE) mechanism of action ARE in certain configurations recruit HuR protein to 3′UTR, presumably preventing in vitro transcribed mRNA degradation. Graph depicts the concept of area under the curve, where stabilization of mRNA allows long-lasting mRNA translation and therapeutic effect.
See this image and copyright information in PMC

References

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