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. 2025 May;18(5):e013465.
doi: 10.1161/CIRCEP.124.013465. Epub 2025 Apr 25.

Long-Term Clinical Benefits of Pulsed Field Ablation in Paroxysmal Atrial Fibrillation: Subanalyses From the Multicenter inspIRE Trial

Collaborators, Affiliations

Long-Term Clinical Benefits of Pulsed Field Ablation in Paroxysmal Atrial Fibrillation: Subanalyses From the Multicenter inspIRE Trial

Tom J R De Potter et al. Circ Arrhythm Electrophysiol. 2025 May.
No abstract available

Keywords: atrial fibrillation; catheters; heart atria; pulmonary veins; tachycardia.

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Conflict of interest statement

Dr De Potter received consulting fees and honoraria for lectures and presentations from Biosense Webster and Adagio Medical (all payments were directed to the institution). Dr Grimaldi has an unrelated patent agreement with Biosense Webster, Inc. Dr Duytschaever has served on the speakers’ bureau and as a consultant for Biosense Webster, Inc, and received research support from Biosense Webster, Inc. Dr Anic received consulting fees and has contracted research with Farapulse, Boston Scientific, Galaxy Medical, and Biosense Webster, Inc. Drs Vijgen, Neuzil, and Scherr received grant support from Biosense Webster, Inc. Dr Van Herendael received support from Biosense Webster, Inc, for congress-related activities. Dr Verma received grants from Biosense Webster, Inc, Medtronic, Bayer, and Biotronik; received consulting fees from Biosense Webster, Inc, Medtronic, Adagio Medical, Galaxy Medical, Ablacon, and Thermedical; and received honoraria for lectures from Biosense Webster, Inc, and Medtronic. Dr Skanes has served on the speakers’ bureau for Biosense Webster, Inc, and received research support from Biosense Webster, Inc. Dr Pürerfellner received consulting fees from Biosense Webster, Inc, Abbott, Boston Scientific, Biotronik, and Medtronic and received payment or honoraria for lectures or presentations from Biosense Webster, Inc, Abbott, Boston Scientific, Biotronik, and Medtronic. Dr Jais received research grants from Biosense Webster, Inc; received speaker fees from Biosense Webster, Inc; is a shareholder of Farapulse/Affera; and received speaker fees and research grants from Boston Scientific, Medtronic, and Abbott. Dr Reddy is a consultant for Biosense Webster, Inc; unrelated to this article, he serves as a consultant for and has equity in Ablacon, Acutus Medical, Affera-Medtronic, Apama Medical-Boston Scientific, Anumana, APN Health, Aquaheart, Atacor, Autonomix, Axon Therapies, Backbeat, BioSig, CardiaCare, CardioNXT/AFTx, Circa Scientific, CoRISMA, Corvia Medical, Dinova-Hangzhou DiNovA EP Technology, East End Medical, EPD-Philips, EP Frontiers, Epix Therapeutics-Medtronic, EpiEP, Eximo, Farapulse-Boston Scientific, Field Medical, Focused Therapeutics, HRT, InterShunt, Javelin, Kardium, Keystone Heart, LuxMed, Medlumics, Middlepeak, Neutrace, Nuvera-Biosense Webster, Oracle Health, Restore Medical, Sirona Medical, SoundCath, and Valcare; unrelated to this work, he has served as a consultant for Abbott, AtriAN, BioTel Heart, Biotronik, Boston Scientific, Cairdac, CardioFocus, Cardionomic, CoreMap, Fire1, Gore & Associates, Impulse Dynamics, Medtronic, Novartis, Philips, and Pulse Biosciences; and he has equity in DRS Vascular, Manual Surgical Sciences, Newpace, Nyra Medical, Surecor, and VizaraMed. Johnson & Johnson MedTech has an agreement with the Yale Open Data Access Project to serve as the independent review panel for evaluation of requests for clinical study reports and participant-level data from investigators and physicians for scientific research that will advance medical knowledge and public health. Requests for access to the study data can be submitted through the Yale Open Data Access Project site at https://yoda.yale.edu. Dr Rackauskas reports no conflicts.

Figures

Figure.
Figure.
Central illustration depicting the study design, significant improvements in Atrial Fibrillation Effect on Quality-of-Life (AFEQT) overall and subscale scores at 12 months, and Kaplan-Meier analysis of clinical benefit success in the inspIRE study. AAD indicates antiarrhythmic drug; AF, atrial fibrillation; CV, cardiovascular; DCCV, direct current cardioversion; inspIRE, Study for Treatment of Paroxysmal Atrial Fibrillation (PAF) by Pulsed Field Ablation (PFA) System With Irreversible Electroporation (IRE); LVEF, left ventricular ejection fraction; MCID, minimal clinically important difference; OR, odds ratio; PVI, pulmonary vein isolation; and QoL, quality of life.

References

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