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Review
. 2025 Mar 31;12(4):125.
doi: 10.3390/jcdd12040125.

Paravalvular Leak in Transcatheter Aortic Valve Implantation: A Review of Current Challenges and Future Directions

Andreas Synetos  1   2 , Nikolaos Ktenopoulos  1 , Odysseas Katsaros  1 , Konstantina Vlasopoulou  1 , Maria Drakopoulou  1 , Leonidas Koliastasis  1 , Ioannis Kachrimanidis  1 , Anastasios Apostolos  1 , Sotirios Tsalamandris  1 , George Latsios  1 , Konstantinos Toutouzas  1 , Ioannis Patrikios  2 , Constantinos Tsioufis  1
Affiliations
Review

Paravalvular Leak in Transcatheter Aortic Valve Implantation: A Review of Current Challenges and Future Directions

Andreas Synetos et al. J Cardiovasc Dev Dis. .

Abstract

Transcatheter aortic valve implantation (TAVI) has emerged as a revolutionary therapeutic modality for the management of severe aortic stenosis (AS), particularly in patients who are at high or prohibitive risk for surgical aortic valve replacement (SAVR). Over the past decade, extensive clinical evidence has expanded the indications for TAVI to include intermediate- and low-risk populations, which usually represent a population of younger age, in which the most common complications of TAVI, including paravalvular leak (PVL) and pacemaker implantation, should be avoided. This review focuses on the incidence and predictors of PVL in various types of TAVI implantation, its clinical implication, and the prevention strategies to tackle this complication.

Keywords: aortic stenosis; paravalvular leak; paravalvular regurgitation; transcatheter aortic valve implantation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Predictors, intra- and post-procedural assessment, and outcomes of paravalvular regurgitation after transcatheter aortic valve implantation (TAVI).
See this image and copyright information in PMC

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