Application of Hydroxyapatite Composites in Bone Tissue Engineering: A Review

Abstract

The treatment of bone defects is complicated by clinical conditions, such as trauma, tumor resection, and infection, which result in defects and impair the bone's regenerative capacity. Hydroxyapatite (HAp), the primary inorganic component of bone, possesses good biocompatibility and osteoconductivity. However, it has poor mechanical properties, a slow degradation rate, and limited functionality, necessitating combination with other materials to broaden its application scope. This paper summarizes the importance and properties of HAp composites and provides a categorized review of current research on HAp composites in bone tissue engineering. These composite scaffolds not only offer excellent mechanical support for cell growth and tissue regeneration but also facilitate new bone formation and vascularization. Additionally, the challenges faced by HAp composites, such as material property optimization and improvement of preparation techniques, are discussed. The paper also summarizes the applications of HAp composites in bone defect repair, dental implants, spinal fusion, and other fields.

Keywords: bioactive ceramics; biocompatibility; biomaterial composites; bone repair; osteogenesis; scaffold.

Figure 1

Literature review framework diagram.

Figure 2

HAp composites can be classified into composites with inorganic materials, composites with organic materials, and multicomponent composites combining both inorganic and organic materials.