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Review
. 2025 Apr 4;23(4):158.
doi: 10.3390/md23040158.

Marine-Derived Bioactive Compounds: A Promising Strategy for Ameliorating Skeletal Muscle Dysfunction in COPD

Affiliations
Review

Marine-Derived Bioactive Compounds: A Promising Strategy for Ameliorating Skeletal Muscle Dysfunction in COPD

Meiling Jiang et al. Mar Drugs. .

Abstract

Chronic obstructive pulmonary disease (COPD) is frequently accompanied by skeletal muscle dysfunction, a critical and severe extrapulmonary complication. This dysfunction contributes to reduced exercise capacity, increased frequency of acute exacerbations, and elevated mortality, serving as an independent risk factor for poor prognosis in COPD patients. Owing to the unique physicochemical conditions of the marine environment, marine-derived bioactive compounds exhibit potent anti-inflammatory and antioxidant properties, demonstrating therapeutic potential for ameliorating COPD skeletal muscle dysfunction. This review summarizes marine-derived bioactive compounds with promising efficacy against skeletal muscle dysfunction in COPD, including polysaccharides, lipids, polyphenols, peptides, and carotenoids. The discussed compounds have shown bioactivities in promoting skeletal muscle health and suppressing muscle atrophy, thereby providing potential strategies for the prevention and treatment of COPD skeletal muscle dysfunction. These findings may expand the therapeutic strategies for managing COPD skeletal muscle dysfunction.

Keywords: COPD; carotenoids; lipids; marine-derived bioactive compounds; peptides; polyphenols; polysaccharides; skeletal muscle dysfunction.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 2
Figure 2
Chemical structures of polysaccharides with potentially therapeutic effects on COPD skeletal muscle dysfunction: (a) Fucoidan, (b) Chitosan.
Figure 3
Figure 3
Chemical structures of lipids with potentially therapeutic effects on COPD skeletal muscle dysfunction: (a) Docosahexaenoic acid, (b) Eicosapentaenoic acid, (c) Docosapentaenoic acid, (d) Fucosterol.
Figure 4
Figure 4
Chemical structures of polyphenols with potentially therapeutic effects to COPD skeletal muscle dysfunction: (a) Diphlorethohydroxycarmalol, (b) Dieckol, (c) 2,7″-phloroglucinol-6,6′-bieckol.
Figure 5
Figure 5
Chemical structures of carotenoids with potentially therapeutic effects on COPD skeletal muscle dysfunction: (a) Astaxanthin, (b) Fucoxanthin, (c) β-carotene, (d) β-cryptoxanthin, (e) Lutein, (f) Zeaxanthin.
Figure 1
Figure 1
The primary pathogenesis of skeletal muscle dysfunction in COPD.
Figure 6
Figure 6
Bioactivities of marine-derived bioactive compounds in relation to COPD skeletal muscle dysfunction.

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