Do SGLT2 Inhibitors Represent a Promising Treatment for Sudden Cardiac Death?

Jose A Navarro-Garcia^#^{1

2

3}, Kevin A Stump^#^{1

2}, Xander H T Wehrens^{4

5

6

7

8

9}

Affiliations

¹ Cardiovascular Research Institute, Baylor College of Medicine, One Baylor Plaza, BCM335, Houston, TX, 77030, USA.
² Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
³ RICORS2040-Renal Network, ISCIII, Madrid, Spain.
⁴ Cardiovascular Research Institute, Baylor College of Medicine, One Baylor Plaza, BCM335, Houston, TX, 77030, USA. wehrens@bcm.edu.
⁵ Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁶ Department of Medicine (Cardiology Section), Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁷ Department of Pediatrics (Cardiology Section), Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁸ Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁹ Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.

^# Contributed equally.

PMID: 40279005
DOI: 10.1007/s10557-025-07707-z

Do SGLT2 Inhibitors Represent a Promising Treatment for Sudden Cardiac Death?

Jose A Navarro-Garcia et al. Cardiovasc Drugs Ther. 2025.

. 2025 Apr 25.

doi: 10.1007/s10557-025-07707-z. Online ahead of print.

Authors

Jose A Navarro-Garcia^#^{1

2

3}, Kevin A Stump^#^{1

2}, Xander H T Wehrens^{4

5

6

7

8

9}

Affiliations

¹ Cardiovascular Research Institute, Baylor College of Medicine, One Baylor Plaza, BCM335, Houston, TX, 77030, USA.
² Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
³ RICORS2040-Renal Network, ISCIII, Madrid, Spain.
⁴ Cardiovascular Research Institute, Baylor College of Medicine, One Baylor Plaza, BCM335, Houston, TX, 77030, USA. wehrens@bcm.edu.
⁵ Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁶ Department of Medicine (Cardiology Section), Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁷ Department of Pediatrics (Cardiology Section), Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁸ Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.
⁹ Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA. wehrens@bcm.edu.

^# Contributed equally.

PMID: 40279005
DOI: 10.1007/s10557-025-07707-z

No abstract available

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Conflict of interest statement

Declarations. Ethics Approval: Not applicable. Consent to Participate: Not applicable. Consent for Publication: Not applicable. Competing Interests: Dr. Wehrens is a consultant to and shareholder of Rocket Pharmaceuticals.

References

1. Marfella R, Scisciola L, D’Onofrio N, et al. Sodium-glucose cotransporter-2 (SGLT2) expression in diabetic and non-diabetic failing human cardiomyocytes. Pharmacol Res. 2022;184:106448. https://doi.org/10.1016/j.phrs.2022.106448 . - DOI - PubMed
1. McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381(21):1995–2008. https://doi.org/10.1056/NEJMoa1911303 . - DOI - PubMed
1. Jhuo SJ, Liu IH, Tsai WC, et al. Effects of secretome from fat tissues on ion currents of cardiomyocyte modulated by sodium-glucose transporter 2 inhibitor. Molecules. 2020;25(16). https://doi.org/10.3390/molecules25163606 .
1. Li HL, Lip GYH, Feng Q, et al. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis. Cardiovasc Diabetol. 2021;20(1):100. https://doi.org/10.1186/s12933-021-01293-8 . - DOI - PubMed - PMC
1. Curtain JP, Docherty KF, Jhund PS, et al. Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF. Eur Heart J. 2021;42(36):3727–38. https://doi.org/10.1093/eurheartj/ehab560 . - DOI - PubMed - PMC

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Do SGLT2 Inhibitors Represent a Promising Treatment for Sudden Cardiac Death?

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Do SGLT2 Inhibitors Represent a Promising Treatment for Sudden Cardiac Death?

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