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. 1985 Sep;69(9):1003-4.

Aminoglutethimide-induced hematologic toxicity: worldwide experience

A A Messeih, A Lipton, R J Santen, H A Harvey, A E Boucher, R Murray, J Ragaz, A U Buzdar, G A Nagel, I C Henderson
  • PMID: 4028032

Aminoglutethimide-induced hematologic toxicity: worldwide experience

A A Messeih et al. Cancer Treat Rep. 1985 Sep.

Abstract

Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

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