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Review
. 2025 Jul;22(7):517-526.
doi: 10.1038/s41575-025-01065-9. Epub 2025 Apr 25.

Common misconceptions and controversies in the management of irritable bowel syndrome

Affiliations
Review

Common misconceptions and controversies in the management of irritable bowel syndrome

Christopher J Black et al. Nat Rev Gastroenterol Hepatol. 2025 Jul.

Abstract

Despite an increase in our understanding of the pathophysiology of irritable bowel syndrome (IBS), in the context of abnormal gut-brain axis communication, and advances in both pharmacological and non-pharmacological treatment of the disorder, there remain areas in which there are misconceptions and controversies in the clinical management of IBS. This Perspective aims to highlight some of the most common misconceptions and controversies in IBS management, including those that the scientific literature has resolved, but for which further education of clinicians dealing with patients with IBS might be required to implement the findings from medical research. Areas of remaining contention are also discussed, as are suggestions as to how these issues could be addressed, both by advances in clinical practice and by further research.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

References

    1. Ford, A. C., Sperber, A. D., Corsetti, M. & Camilleri, M. Irritable bowel syndrome. Lancet 396, 1675–1688 (2020). - PubMed - DOI
    1. Sperber, A. D. et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation global study. Gastroenterology 160, 99–114 (2021). - PubMed - DOI
    1. Oka, P. et al. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. Lancet Gastroenterol. Hepatol. 5, 908–917 (2020). - PubMed - DOI
    1. Ford, A. C., Forman, D., Bailey, A. G., Axon, A. T. R. & Moayyedi, P. Irritable bowel syndrome: a 10-year natural history of symptoms, and factors that influence consultation behavior. Am. J. Gastroenterol. 103, 1229–1239 (2008). - PubMed - DOI
    1. Drossman, D. A. & Hasler, W. L. Rome IV–functional GI disorders: disorders of gut-brain interaction. Gastroenterology 150, 1257–1261 (2016). - PubMed - DOI

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