Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Apr 25;25(1):104.
doi: 10.1186/s12894-025-01790-y.

Sarcomatoid prostate carcinoma: a case report

Hamza Hafiani  1 , Ismail Hafiani  2 , Mohamed Hafiani  3
Affiliations
Case Reports

Sarcomatoid prostate carcinoma: a case report

Hamza Hafiani et al. BMC Urol. .

Abstract

Background: Sarcomatoid carcinoma of the prostate is an extremely rare and aggressive variant of prostate cancer, posing significant diagnostic and therapeutic challenges due to its mixed histological features. It represents less than 0.1% of prostate cancer cases and is characterized by the presence of both glandular and sarcomatoid components.

Case presentation: We report the case of a 58-year-old male from rural Morocco who presented with a two-month history of urinary symptoms. Initial imaging revealed prostatic enlargement and a PSA level of 9ng/l, prompting further investigation with CT imaging, which identified a significant prostatic abscess. Surgical drainage unexpectedly revealed a hard mass, leading to transrectal biopsies and subsequent histopathological analysis confirming the diagnosis of sarcomatoid prostate carcinoma. The patient underwent radical prostatectomy post-diagnosis.

Conclusions: Sarcomatoid carcinoma of the prostate remains a diagnostic challenge due to its rarity and mixed histological features. This case highlights the importance of considering sarcomatoid carcinoma in the differential diagnosis of prostate malignancies, especially in patients with atypical presentations such as prostatic abscesses. Early recognition and appropriate management are crucial for optimizing patient outcomes in such cases.

Keywords: Case report; Histopathology; Prostate Cancer; Prostatic neoplasms; Sarcomatoid carcinoma.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. There is no ethics committee in our hospital and this is a case report where written consent was obtained. Consent for publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests: The authors declare no competing interests.

Figures

Fig. A
Fig. A
Axial view of CT scan showing a prostatic abscess
Fig. B
Fig. B
Blue arrow showing areas of chondrosarcomatous differentiation and Purple arrow showing areas of classic adenocarcinoma
Fig. C
Fig. C
Area of osteosarcomatous differentiation
See this image and copyright information in PMC

References

    1. Açıkgöz O, Gazel E, Zengin Nİ, Kasap Y, Çamtosun A, Yazıcıoğlu AH. Sarcomatoid carcinoma of the prostate. Case Rep Urol. 2013;2013:1–3. - PMC - PubMed
    1. Huan Y, Idrees M, Gribetz ME, Unger PD. Sarcomatoid carcinoma after radiation treatment of prostatic adenocarcinoma. Ann Diagn Pathol Avr. 2008;12(2):142–5. - PubMed
    1. Hansel DE, Epstein JI. Sarcomatoid carcinoma of the prostate: A study of 42 cases. Am J Surg Pathol Oct. 2006;30(10):1316–21. - PubMed
    1. Markowski MC, Eisenberger MA, Zahurak M, Epstein JI, Paller CJ. Sarcomatoid carcinoma of the prostate: retrospective review of a case series from the Johns Hopkins hospital. Urol Sept. 2015;86(3):539–43. - PMC - PubMed
    1. Zhang Z, Wang Y, Zhao Q, Li G, Zhao X, Li J. Mixed adenocarcinoma, sarcomatoid carcinoma and adenosquamous carcinoma of the prostate: A case report. Oncol Lett Nov. 2014;8(5):2325–7. - PMC - PubMed

Publication types