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Review
. 2025 Apr 9;17(8):1276.
doi: 10.3390/cancers17081276.

Patient Positioning and Treatment Techniques in Total Skin Irradiation: A Scoping Review

Andrea Lastrucci  1   2 , Emanuele Canzani  3 , Neda Haghighatjou  1   2 , Livia Marrazzo  4   5 , Nicola Iosca  1   2 , Yannick Wandael  1 , Daniele Giansanti  6 , Renzo Ricci  1 , Monica Mangoni  2   5 , Stefania Pallotta  4   5 , Gabriele Simontacchi  2 , Lorenzo Livi  5
Affiliations
Review

Patient Positioning and Treatment Techniques in Total Skin Irradiation: A Scoping Review

Andrea Lastrucci et al. Cancers (Basel). .

Abstract

Introduction: Total skin irradiation (TSI) is a radiotherapy technique used to treat cutaneous lymphomas, such as mycosis fungoides. A key aspect of the success of the treatment is the correct positioning of the patient, which ensures a homogeneous distribution of radiation over the skin surface, minimizing exposure to the surrounding healthy tissues. Materials and Methods: Following the preferred reporting items for systematic review and meta-analysis (PRISMA) extension for scoping reviews and the Arksey and O'Malley framework, electronic searches of EMBASE, PubMed, SCOPUS, and the Web of Science were conducted to identify original studies detailing positioning techniques for TSI in clinical practice. Results: A total of 44 studies were included, reporting a range of positioning techniques used in TSI. The selected articles were divided into four categories: Stanford, rotational, tomotherapy, and mixed (including studies comparing two or more of the previously mentioned techniques). Articles concerning the Stanford technique were predominant (n = 33; 75.0%), followed by those addressing the rotational technique (n = 5; 11.4%), tomotherapy (n = 3; 6.8%), and mixed (n = 3; 6.8%). Studies on the Stanford technique described both the original method and its modifications, including variations such as the lying position, and analyzed its strengths and limitations. Research on the rotational method examined different device configurations and implementation strategies to optimize dose distribution and treatment efficiency. Mixed articles compared the Stanford and rotational techniques, highlighting their similar dose uniformity while examining differences in treatment efficiency and practical implementation. Conclusions: Despite its widespread use, the Stanford technique is associated with challenges that have led to the exploration of alternative positioning strategies. The rotational technique addresses some of these limitations, while tomotherapy offers advanced immobilization but raises toxicity concerns. Future research should focus on optimizing the balance between efficacy, safety, and practicality of treatment in clinical settings.

Keywords: patient positioning; radiotherapy; total skin electron irradiation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart of study selection.
Figure 2
Figure 2
Retrieved articles are categorized based on the TSI technique used.
See this image and copyright information in PMC

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