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. 2025 Apr 9;14(8):2577.
doi: 10.3390/jcm14082577.

COVID-19 Infection in Pediatric Patients Presenting to a Tertiary Center in Jordan: Clinical Characteristics and Age-Related Patterns

Montaha Al-Iede  1   2 , Marah Dannoun  1   2 , Iyad Al-Ammouri  3   4 , Enas Al-Zayadneh  1   2 , Amirah Daher  2   4 , Jumana Albaramki  2   5 , Danah Alsmady  1   2 , Omar Husain  1   2 , Batool Abusabra  1   2 , Rima A Sinan  1   2 , Lena Sarhan  1   2
Affiliations

COVID-19 Infection in Pediatric Patients Presenting to a Tertiary Center in Jordan: Clinical Characteristics and Age-Related Patterns

Montaha Al-Iede et al. J Clin Med. .

Abstract

Objectives: This study assessed the clinical characteristics of pediatric COVID-19 patients across different age groups during the first and second pandemic waves in Jordan. Methods: A retrospective analysis was conducted at Jordan University Hospital, involving 485 patients aged 1 month to 18 years from September 2020 to July 2021. Patients were categorized into preschool (≤5 years), school-aged (6-10 years), and teenagers (>10 years). Patients' clinical characteristics were analyzed using R (version 2.3.3). Results: The mean age for participants was 10.7 ± 5.7 years. Shortness of breath, abdominal pain, and headaches were significantly more likely among older participants (all p < 0.01). Conversely, younger patients were more likely to experience nasal congestion, decreased activity, and reduced feeding (all p < 0.05). The majority of patients had mild symptom severity. Analysis of physiologic and laboratory parameters demonstrated significant differences among age groups in terms of heart rate, respiratory rate, hemoglobin, neutrophils, lymphocytes, platelets, CRP, and creatinine (all p < 0.05). Respiratory support was mainly observed among younger patients. Antibiotics was the most commonly received medication. In terms of outcomes, two patients had complications during their stay, both of which belonged to the <5 years age group. We observed significant differences in incidence of symptoms and laboratory markers among different pediatric age groups. While younger patients experienced severe complications, their older counterparts exhibited more alarming symptoms and worse counts of immune cells. Conclusions: These findings highlight the importance of age-specific management strategies for COVID-19, emphasizing the need for tailored approaches in both treatment and prevention.

Keywords: COVID-19; management; outcome; pandemic; symptoms.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
COVID-19 severity stratified by admission status.
Figure 2
Figure 2
Age groups stratified by admission status.
See this image and copyright information in PMC

References

    1. CDC Centers for Disease Control and Prevention (2021)’ COVID-2019 Case Tracker for Jordan. [(accessed on 27 March 2025)];2024 Available online: https://.www.cdc.gov.
    1. Sallam M., Mahafzah A. Molecular Analysis of SARS-CoV-2 Genetic Lineages in Jordan: Tracking the Introduction and Spread of COVID-19 UK Variant of Concern at a Country Level. Pathogens. 2021;10:302. doi: 10.3390/pathogens10030302. - DOI - PMC - PubMed
    1. Markov P.V., Ghafari M., Beer M., Lythgoe K., Simmonds P., Stilianakis N.I., Katzourakis A. The evolution of SARS-CoV-2. Nat. Rev. Microbiol. 2023;21:361–379. doi: 10.1038/s41579-023-00878-2. - DOI - PubMed
    1. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z., Tong S. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145:e20200702. doi: 10.1542/peds.2020-0702. - DOI - PubMed
    1. Ludvigsson J.F. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109:1088–1095. doi: 10.1111/apa.15270. - DOI - PMC - PubMed

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