Nutrition and Gut Microbiota-Immune System Interplay in Chronic Diseases

Flávio Reis^{1

2

3

4}, Leonardo M R Ferreira^{5

6}, Eduardo Ortega^{7

8}, Sofia Viana^{1

2

3

4

9

10}

Affiliations

¹ Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
² Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
³ Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-531 Coimbra, Portugal.
⁴ Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal.
⁵ Department of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
⁶ Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
⁷ Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006 Badajoz, Spain.
⁸ Immunophysiology Research Group, Physiology Department, Faculty of Sciences, University of Extremadura, 06006 Badajoz, Spain.
⁹ Polytechnic Institute of Coimbra, 3045-093 Coimbra, Portugal.
¹⁰ H&TRC-Health and Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, 3045-093 Coimbra, Portugal.

PMID: 40284195
PMCID: PMC12030219
DOI: 10.3390/nu17081330

Editorial

Nutrition and Gut Microbiota-Immune System Interplay in Chronic Diseases

Flávio Reis et al. Nutrients. 2025.

. 2025 Apr 11;17(8):1330.

doi: 10.3390/nu17081330.

Authors

Flávio Reis^{1

2

3

4}, Leonardo M R Ferreira^{5

6}, Eduardo Ortega^{7

8}, Sofia Viana^{1

2

3

4

9

10}

Affiliations

¹ Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
² Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
³ Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-531 Coimbra, Portugal.
⁴ Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal.
⁵ Department of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
⁶ Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
⁷ Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006 Badajoz, Spain.
⁸ Immunophysiology Research Group, Physiology Department, Faculty of Sciences, University of Extremadura, 06006 Badajoz, Spain.
⁹ Polytechnic Institute of Coimbra, 3045-093 Coimbra, Portugal.
¹⁰ H&TRC-Health and Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, 3045-093 Coimbra, Portugal.

PMID: 40284195
PMCID: PMC12030219
DOI: 10.3390/nu17081330

Abstract

Non-communicable diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular diseases, allergies, and cancer are escalating global health concerns [...].

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Conflict of interest statement

The authors declare no conflicts of interest.

References

1. Furman D., Campisi J., Verdin E., Carrera-Bastos P., Targ S., Franceschi C., Ferrucci L., Gilroy D.W., Fasano A., Miller G.W., et al. Chronic Inflammation in The Etiology of Disease Across The Life Span. Nat. Med. 2019;25:1822–1832. doi: 10.1038/s41591-019-0675-0. - DOI - PMC - PubMed
1. Ramos M.G., Samouda H., Bohn T. Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability. Nutrients. 2022;14:5361. doi: 10.3390/nu14245361. - DOI - PMC - PubMed
1. Xie Z., Sun Y., Ye Y., Hu D., Zhang H., He Z., Zhao H., Yang H., Mao Y. Randomized Controlled Trial for Time-Restricted Eating in Healthy Volunteers Without Obesity. Nat. Commun. 2022;13:1003. doi: 10.1038/s41467-022-28662-5. - DOI - PMC - PubMed
1. Katona P., Katona-Apte J. The interaction between nutrition and infection. Clin. Infect. Dis. 2008;46:1582–1588. doi: 10.1086/587658. - DOI - PubMed
1. Gershteyn I.M., Ferreira L.M.R. Immunodietica: A Data-Driven Approach To Investigate Interactions Between Diet And Autoimmune Disorders. J. Transl. Autoimmun. 2019;1:100003. doi: 10.1016/j.jtauto.2019.100003. - DOI - PMC - PubMed

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Nutrition and Gut Microbiota-Immune System Interplay in Chronic Diseases

Affiliations

Nutrition and Gut Microbiota-Immune System Interplay in Chronic Diseases

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical