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Review
. 2025 Mar;26(Suppl 1):1-17.
doi: 10.1007/s11121-025-01801-2. Epub 2025 Apr 26.

An Integrated Review of Findings from the Early Head Start University Partnerships Buffering Toxic Stress Consortium

Neda Senehi  1 , Aleta Meyer  2 , Mary Bruce Webb  1 , Sangeeta Parikshak  3 , Alysia Blandon  1
Affiliations
Review

An Integrated Review of Findings from the Early Head Start University Partnerships Buffering Toxic Stress Consortium

Neda Senehi et al. Prev Sci. 2025 Mar.

Abstract

This paper introduces the special issue of Prevention Science titled Applied Prevention Science to Inform Parenting Enhancements to Early Head Start that Promote Supportive Parent-Child Interactions and Buffer the Detrimental Effects of Early Adversity. We provide an integrative overview of the Early Head Start-University Partnerships Buffering Toxic Stress (BTS) consortium, funded by the Administration for Children and Families (ACF), summarizing key findings from six studies and reflecting on their implications in light of recent ACF and Office of Head Start (OHS) policies and regulations. Programs such as Early Head Start (EHS), which integrate parenting support and skill-building, have demonstrated effectiveness in enhancing parental competencies, reducing stress, and improving child outcomes. However, intervention effects remain modest and vary significantly by factors such as race and ethnicity, demographic risk, and family characteristics. This variability underscores the need for tailored, culturally responsive approaches that validate and refine frameworks for understanding parental and social buffering of children's toxic stress response. Findings from the BTS studies highlight promising program impacts, especially for families facing heightened risk, such as those with maternal histories of adverse childhood experiences or ongoing mental health challenges. This synthesis reinforces the importance of precision-based, contextually responsive interventions and aligns with recent ACF and OHS regulations aimed at developing scalable, cost-effective models that meet the unique needs of families experiencing adversity. Beyond EHS, we hope this special issue advances the field of applied prevention science by informing the development of tailored, effective, and sustainable programming for children and families navigating early adversity.

Keywords: Buffering; Early Head Start; Parenting enhancements; Precision home-visiting; Toxic stress response.

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Conflict of interest statement

Declarations. All authors are affiliated with the Administration for Children and Families, US Department of Health and Human Services, Washington, DC, United States. Neda Senehi PhD was a Society for Research in Child Development Federal Executive Branch Science and Technology Policy Fellow in the Office of Planning Research and Evaluation (OPRE) within ACF from 2021 to 2023; Aleta Meyer PhD and Alysia Blandon PhD are currently in OPRE within ACF; Mary Bruce Webb PhD is retired from OPRE; Sangeeta Parikshak PhD is currently in the Office of Head Start within ACF. Ethical Approval: This paper is a review of studies and did not involve original human subjects. Each study itself had approved human subjects review and ethics approval. Consent to Participate: This paper is a review of studies and did not involve original human subjects. Each study itself had approved human subjects review and informed consent. Conflict of Interest: The authors declare no competing interests.

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