Exploring starch-based excipients in pharmaceutical formulations: Versatile applications and future perspectives

Abstract

Starch, a naturally abundant and biocompatible polysaccharide, serves as a key excipient in pharmaceutical formulations, enhancing drug stability, efficacy, and manufacturability. This review explores the properties, modifications, and diverse applications of starch-based excipients. Native starches from corn, potato, rice, and wheat are commonly used as disintegrants, binders, and fillers. Physical (e.g., pre-gelatinization), chemical (e.g., cross-linking, acetylation), and enzymatic modifications improve their functionality, such as enhanced stability and colon-specific drug delivery. Starch excels as a binder, improving tablet cohesion and strength, and as a disintegrant, promoting rapid drug release. It also supports controlled and sustained-release systems and advanced drug delivery methods, like nanoparticles and microparticles. Compared to other natural and synthetic excipients, starch offers advantages in biodegradability, non-toxicity, and cost-effectiveness, despite challenges like stability and batch variability. Innovations such as starch nanocrystals show promise in boosting drug solubility and bioavailability. Looking ahead, starch-based excipients hold potential for sustainable pharmaceutical development, personalized medicine, and 3D printing.

Keywords: Binder; Controlled release; Disintegrant; Drug delivery; Hydrogel; Starch.