Shape-adaptive, deformable and adhesive hydrogels enable stable closure of long incision wounds

Abstract

Effective closure of long incision wounds is crucial in clinical practice but remains challenging for existing bioadhesives due to the deformations of the long incisions. Herein, we propose a concept of shape-adaptive adhesion and achieve it by designing a class of shape-adaptive, deformable adhesive hydrogels (DAHs) for long incision wound closure. The design strategy is facile yet universally applicable, which involves aldehyde polysaccharides as adhesive primers and microgel-type gelators as building blocks. We demonstrate that the microgel-type gelators are responsible for the integration of a deformable matrix in situ, and aldehyde polysaccharides enhance the adhesive performance of the matrix at cost of a little deformability. Optimization of the flexibility of DAH network is effective in balancing the adhesive and deformable properties, thus developing DAHs featured with the adaptability to irregular shapes, robust adhesive properties, and appropriate deformability. As a result, DAHs achieve shape-adaptive adhesion by effectively bonding the long incision and deforming with it without failure. In vivo results clearly show that DAHs stably close the 4 cm-long incision wounds on the backs and the more dynamic incisions on the napes of rats. The shape-adaptive adhesion achieved by DAHs may provide an alternative way for long incision wound treatment. STATEMENT OF SIGNIFICANCE: Bioadhesive is emerging as an effective tool in clinical wound treatment. However, the closure of severe long incision wounds by currently available bioadhesives is still challenging. In this work, we proposed a concept of shape-adaptive adhesion and accordingly developed a bioadhesive building strategy for long incision wound closure. The strategy is universally applicable, which involves aldehyde polysaccharide as an adhesive primer and microgel-type gelators as building blocks. The results showed that the strategy is effective in developing bioadhesives (DAHs) that simultaneously possess shape-adaptive properties, robust adhesive properties and appropriate deformability, thus overcoming the limitations of most existing bioadhesives. With these features, DAHs successfully achieved shape-adaptive adhesion and stable closure of long incision wounds, providing an effective way for wound treatment.

Keywords: Adhesive hydrogel; Aldehyde polysaccharide; Deformability; Long incision wound; Tissue-adhesiveness.