Review

. 2025 Jun;67(2):100666.

doi: 10.1016/j.job.2025.100666. Epub 2025 Apr 24.

Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease

Haruhisa Watanabe¹, Riyu Koguchi², Takashi S Kajii³, Yutaka Maruoka⁴, Tadahiro Iimura⁵

Affiliations

¹ Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan.
² Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan; Department of Oral Diagnosis and Medicine, Hokkaido University, Faculty and Graduate School of Dental Medicine, Sapporo, 060-8586, Japan.
³ Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan; Department of Orthodontics, Keiyu-kai Sapporo Hospital, Sapporo, 060-0061, Japan.
⁴ Department of Oral Surgery, Center Hospital, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
⁵ Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan. Electronic address: iimura@den.hokudai.ac.jp.

PMID: 40287135
DOI: 10.1016/j.job.2025.100666

Free article

Review

Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease

Haruhisa Watanabe et al. J Oral Biosci. 2025 Jun.

Free article

. 2025 Jun;67(2):100666.

doi: 10.1016/j.job.2025.100666. Epub 2025 Apr 24.

Authors

Haruhisa Watanabe¹, Riyu Koguchi², Takashi S Kajii³, Yutaka Maruoka⁴, Tadahiro Iimura⁵

Affiliations

¹ Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan.
² Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan; Department of Oral Diagnosis and Medicine, Hokkaido University, Faculty and Graduate School of Dental Medicine, Sapporo, 060-8586, Japan.
³ Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan; Department of Orthodontics, Keiyu-kai Sapporo Hospital, Sapporo, 060-0061, Japan.
⁴ Department of Oral Surgery, Center Hospital, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
⁵ Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan. Electronic address: iimura@den.hokudai.ac.jp.

PMID: 40287135
DOI: 10.1016/j.job.2025.100666

Abstract

Background: Chemokine receptor 5 (CCR5)-mediated signals are involved in various biological responses and inflammatory diseases. Recent studies have revealed the roles of this signaling pathway in bone metabolism, metabolic bone diseases, and joint diseases.

Highlight: Through preclinical and clinical studies, our research group has demonstrated that CCR5 signaling is deeply involved in degenerative changes in the temporomandibular joint (TMJ).

Conclusion: In this short review, we outline the diverse functions of CCR5 signaling in oral and degenerative TMJ diseases.

Keywords: Bone; CCL5; CCR5; Joint; Oral disease.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

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Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease

Affiliations

Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease

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