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Review
. 2025 May;29(2):165-184.
doi: 10.1016/j.cld.2024.12.001. Epub 2025 Jan 30.

Liver Transplantation in Alcohol-Associated Liver Disease

Elias D Rady  1 , Ahmad Anouti  1 , Chanattha Thimphitthaya  2 , Thomas G Cotter  3
Affiliations
Review

Liver Transplantation in Alcohol-Associated Liver Disease

Elias D Rady et al. Clin Liver Dis. 2025 May.

Abstract

Alcohol-associated liver disease (ALD) is the foremost cause of liver-related mortality in the United States comprising a spectrum of conditions from simple hepatic steatosis to more severe alcohol-associated cirrhosis and alcohol-associated hepatitis. There has been growing acceptance and application of early liver transplantation (eLT) for ALD. There is robust evidence for excellent patient and graft survival rates for eLT for ALD. Nevertheless, recidivism remains a major concern. This article aims to explore the recent trends in liver transplantation for ALD, as well as the advances in practice and outcomes, with focus on eLT and emerging challenges in this field.

Keywords: Alcohol use disorder; Alcohol-associated cirrhosis; Alcohol-associated hepatitis; Alcohol-associated liver disease; Liver transplantation.

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Conflict of interest statement

Conflicts of Interest

ER, AA, and CT have no financial disclosures.

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