Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2025 Aug:73:152736.
doi: 10.1016/j.semarthrit.2025.152736. Epub 2025 Apr 16.

Factors associated with thrombosis in Behçet Syndrome: A systematic review and meta-analysis

Gul Guzelant-Ozkose  1 , Berna Yurttas  1 , Sinem Nihal Esatoglu  2 , Muhlis Cem Ar  3 , Vedat Hamuryudan  4 , Gulen Hatemi  4
Affiliations
Meta-Analysis

Factors associated with thrombosis in Behçet Syndrome: A systematic review and meta-analysis

Gul Guzelant-Ozkose et al. Semin Arthritis Rheum. 2025 Aug.

Abstract

Objectives: Thrombosis is an important component of vascular involvement in Behçet syndrome (BS). Inflammation seems to be the main cause, while the contribution of factors associated with thrombosis is debated.

Methods: We searched PubMed and EMBASE for studies that assessed factors associated with thrombosis in patients with BS. We separately analyzed studies that compared BS patients with thrombosis to BS patients without thrombosis and studies that compared BS patients with thrombosis to non-BS patients with thrombosis. The pooled odds ratios with 95%CI were calculated for binary outcomes and standardized mean differences were calculated for continuous outcomes.

Results: A total of 87 factors were compared between BS patients with thrombosis and BS patients without thrombosis in 101 studies. Having a Factor V Leiden mutation increased the risk of thrombosis 2.58 times (95% CI 1.76 to 3.78) among patients with BS. Homocysteine levels and factor VIII levels were also significantly higher among BS patients with thrombosis. There were only 6 studies including 14 factors that compared BS patients with thrombosis to non-BS patients with thrombosis. The frequencies of JAK-2 mutation, activated protein C resistance, levels of tissue plasminogen activator (tPA) and activity of tPA were significantly higher among non-BS patients with thrombosis.

Conclusion: Prothrombotic factors do not seem to be the main driver of thrombosis in BS, but may pose an additional risk when present. Screening BS patients with thrombosis for common prothrombotic factors may be reasonable, especially in patients with unusual clinical and demographic features for vascular involvement of BS.

Keywords: Behçet’s syndrome; Systematic review; Thrombophilia; Thrombosis.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Gulen Hatemi reports a relationship with Abbvie, Amgen, Boehringer Ingelheim, Deva Pharmaceuticals, Novartis, Pfizer, Soligenix, and UCB Pharma that includes: consulting or advisory, funding grants, and speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources