RETRACTION: Downregulation of miR-122 in the Rodent and Human Hepatocellular Carcinomas

Abstract

H. Kutay, S. Bai, J. Datta, T. Motiwala, I. Pogribny, W. Frankel, S. T. Jacob, and K. Ghoshal, "Downregulation of miR-122 in the Rodent and Human Hepatocellular Carcinomas," Journal of Cellular Biochemistry 99, no. 3 (2006): 671-678. https://doi.org/10.1002/jcb.20982. The above article, published online on 30 June 2006, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. An investigation of alleged research misconduct by The Ohio State University found evidence that false data was included in Figure 4 A by using the 5S RNA Northern blot data for human HCC (tumor (T) and Normal (N) cells) between this article and Figure 2 in another article by many of the same authors (Meng et al. 2007 [https://doi.org/10.1053/j.gastro.2007.05.022]). The investigation confirmed that the 5S RNA data in this article was flipped horizontally as compared to the T/N samples in Meng et al. 2007. An investigation by the publisher also confirmed the evidence of image duplication and manipulation. This retraction has been agreed to because the evidence of image duplication and manipulation compromises the integrity of the study and the conclusions presented in the article. The authors did not respond to the notice regarding the retraction.