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. 2025 Apr 1:15:1561778.
doi: 10.3389/fcimb.2025.1561778. eCollection 2025.

Current rates of Helicobacter pylori infection and antibiotic resistance in the eastern coast of China: a single center study

Hui-Jin Chen #  1 , Yu-Ting Si #  2 , Luan Luan #  2 , Jin-Xin Lai  3 , Ji-Liang Wang  1 , Yu-Rong Tang  1 , Liang Wang  3   4
Affiliations

Current rates of Helicobacter pylori infection and antibiotic resistance in the eastern coast of China: a single center study

Hui-Jin Chen et al. Front Cell Infect Microbiol. .

Abstract

Background: Helicobacter pylori (H. pylori), linked to gastric cancer, lacks regional data on infection rates, resistance, and risks in Dongying, China.

Methods: A pilot study (N = 314) using non-invasive string tests and qPCR assessed H. pylori prevalence and antibiotic resistance. Logistic regression identified risk factors from survey data.

Results: The H. pylori infection rate in Dongying was 24.84% (78/314, 95% CI: 20.06%-29.62%). Of the infected individuals, 60.25% (47/78, 95% CI: 49.40%-71.12%) and 46.15% (36/78, 95% CI: 35.09%-57.22%) showed resistance to clarithromycin and levofloxacin, respectively.

Conclusions: This pilot study provides preliminary data with valuable insights for preventing the transmission of H. pylori infection among the urban population in the East Coast region of China and offers guidance for the personalized treatment of drug-resistant H. pylori infections.

Keywords: H. pylori; antibiotic resistance; prevalence; qPCR; string test.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
The flowchart of the string test gastric fluid sample collection procedure.
See this image and copyright information in PMC

References

    1. Beal C. B., Viens P., Grant R. G., Hughes J. M. (1970). A new technique for sampling duodenal contente. Demonstration of upper small-bowel pathogens. Am J Trop Med Hyg 19(2):349–52. doi: 10.4269/ajtmh.1970.19.349 - DOI - PubMed
    1. Burucoa C., Axon A. (2017). Epidemiology of Helicobacter pylori infection. Helicobacter 22, e12403. doi: 10.1111/hel.2017.22.issue-S1 - DOI - PubMed
    1. Chen J., Li P., Huang Y., Guo Y., Ding Z., Lu H. (2022). Primary antibiotic resistance of Helicobacter pylori in different regions of China: a systematic review and meta-analysis. Pathogens 11, 786. doi: 10.3390/pathogens11070786 - DOI - PMC - PubMed
    1. Chiang T. H., Chang W. J., Chen S. L., Yen A. M., Fann J. C., Chiu S. Y., et al. . (2021). Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands. Gut 70, 243–250. doi: 10.1136/gutjnl-2020-322200 - DOI - PMC - PubMed
    1. Consultation W. (2000). Obesity: preventing and managing the global epidemic. World Health Organ. Tech. Rep. Ser. 894, 1–253. - PubMed

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