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. 2025 Mar 20;17(6):1092.
doi: 10.3390/nu17061092.

Impact of Alcohol Intake on Body Composition in Patients with Steatotic Liver Disease

Masahiro Matsui  1 , Akira Fukuda  2 , Saori Onishi  1 , Kosuke Ushiro  1 , Tomohiro Nishikawa  1 , Akira Asai  1 , Soo Ki Kim  3 , Hiroki Nishikawa  1
Affiliations

Impact of Alcohol Intake on Body Composition in Patients with Steatotic Liver Disease

Masahiro Matsui et al. Nutrients. .

Abstract

Objectives: To examine the effect of alcohol intake on body composition in patients with steatotic liver disease (SLD). Methods: In men, group A (n = 819) was defined as non-drinkers, group B (n = 1147) as <30 g of ethanol equivalent per day, group C (n = 125) as between 30 and 60 g/day, and group D (n = 344) as >60 g/day. In women, group A (n = 749) was defined as non-drinkers, group B (n = 354) as <20 g/day, group C (n = 36) as between 20 and 50 g/day, and group D (n = 68) as >50 g/day. The fat-free (FF) index and fat (F) index were defined as FF mass and F mass divided by height squared (kg/m2). Results: The average FF index and F index in groups A, B, C, and D in men were 19.01, 19.29, 18.50, and 18.55 kg/m2 (overall p < 0.0001), and 6.28, 6.71, 5.66, and 6.03 kg/m2 (overall p < 0.0001). The average FF index and F index in groups A, B, C, and D in women were 16.03, 15.96, 15.62, and 15.07 kg/m2 (overall p < 0.0001), and 9.89, 9.02, 9.32, and 7.53 kg/m2 (overall p < 0.0001). Conclusions: Heavy drinking has a negative effect on skeletal muscle and fat, but complete abstinence from alcohol may not be necessary in SLD patients.

Keywords: alcohol; fat mass; fat-free mass; steatotic liver disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
FF index (A) and F index (B) among four groups in men (n = 2435). Group A was defined as non-drinkers, group B as those who drank less than 30 g of ethanol equivalent per day, group C as those who drank between 30–60 g of ethanol equivalent per day, and group D as those who drank more than 60 g of ethanol equivalent per day.
Figure 2
Figure 2
FF index (A) and F index (B) among four groups in women (n = 1207). Group A was defined as non-drinkers, group B as those who drank less than 20 g of ethanol equivalent per day, group C as those who drank between 20–50 g of ethanol equivalent per day, and group D as those who drank more than 50 g of ethanol equivalent per day.
Figure 3
Figure 3
FF index (A) and F index (B) among four groups in men with BMI > 25 kg/m2 (n = 1177).
Figure 4
Figure 4
FF index (A) and F index (B) among four groups in men with BMI ≤ 25 kg/m2 (n = 1258).
Figure 5
Figure 5
FF index (A) and F index (B) among four groups in women with BMI > 25 kg/m2 (n = 569).
Figure 6
Figure 6
FF index (A) and F index (B) among four groups in women with BMI ≤ 25 kg/m2 (n = 638).
See this image and copyright information in PMC

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