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. 2025 Jul 1;6(4):280-283.
doi: 10.1158/2643-3230.BCD-25-0083.

Putting AML Differentiation States on the BoneMarrowMap

Jonas Berger  1 , Livius Penter  1   2   3
Affiliations

Putting AML Differentiation States on the BoneMarrowMap

Jonas Berger et al. Blood Cancer Discov. .

Abstract

This article presents a novel computational tool, "BoneMarrowMap," that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By utilizing BoneMarrowMap for a large-scale single-cell RNA sequencing reanalysis, the authors discover 12 recurrent acute myeloid leukemia differentiation patterns linked to prognosis and treatment and dissect leukemic clonal architectures within individual patients. See related article by Zeng and colleagues, p. 307.

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Conflict of interest statement

No disclosures were reported.

Comment on

  • 2643-3230. doi: 10.1158/2643-3230.BCD-24-0342

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References

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