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Meta-Analysis
. 2025 Apr 25;104(17):e41915.
doi: 10.1097/MD.0000000000041915.

Impact of age on degenerative joint disease of the temporomandibular joint: A systematic review and meta-analysis

Zhiyuan Wu  1 , Yi Lin, Youlai Lin
Affiliations
Meta-Analysis

Impact of age on degenerative joint disease of the temporomandibular joint: A systematic review and meta-analysis

Zhiyuan Wu et al. Medicine (Baltimore). .

Abstract

Background: It is unclear that the influence of age on degenerative joint disease (DJD) of the temporomandibular joint (TMJ).

Methods: Relevant literature was retrieved from PubMed, Elsevier, Web of Science, and Google Scholar. EndNote 21 was used to consolidate the literature retrieved from these databases. Key information were extracted from the included studies, statistical analysis was performed using Stata 15.0. The quality of the studies was evaluated using the cross-sectional study evaluation criteria recommended by the Agency for Healthcare Research and Quality.

Results: A total of 11 studies involving 2832 participants (1099 males, 1744 females) were included. The incidence of DJD of the TMJ was approximately 35% among individuals aged 20 to 39, 43% among those aged 40 to 59, and 54% among those aged 60-69.

Conclusion: Age progression is a key risk factor for the development of DJD of the TMJ. The incidence of DJD of the TMJ increases progressively across different age groups, with a significant rise observed in middle to older age groups.

Keywords: age; degenerative joint disease of the temporomandibular joint; influencing factors; meta-analysis; temporomandibular joint.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Literature inclusion process.
Figure 2.
Figure 2.
Forest plot of combined mean age for patients with temporomandibular joint DJD. DJD = degenerative joint disease.
Figure 3.
Figure 3.
Forest plot of combined mean age for patients without temporomandibular joint DJD. DJD = degenerative joint disease.
Figure 4.
Figure 4.
Forest plot of the meta-analysis on the association between age and temporomandibular joint DJD. DJD = degenerative joint disease.
See this image and copyright information in PMC

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