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Published Erratum
. 2025 Apr 28;31(1):156.
doi: 10.1186/s10020-025-01214-5.

Correction: S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling

Wenyi Cai #  1 , Antong Wu #  1   2 , Zhongxiao Lin #  3   4 , Wei Cao  1 , Janak L Pathak  1 , Richard T Jaspers  1   2 , Rui Li  1 , Xin Li  1 , Kaihan Zheng  1 , Yufu Lin  1 , Na Zhou  3 , Xin Zhang  3 , Yizhun Zhu  5 , Qingbin Zhang  6
Affiliations
Published Erratum

Correction: S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling

Wenyi Cai et al. Mol Med. .
No abstract available

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Figures

Fig. 6
Fig. 6
SPRC reduced condylar chondrocytes ECM catabolism in vitro. (A) Representative images of condylar chondrocytes stained with toluidine blue to assess extracellular matrix (ECM) integrity. (B) Immunofluorescence staining of chondrocytes showing DAPI-stained nuclei (blue), phalloidin-stained F-actin (green), and COL2A1 (red). (C) Cell viability of rat primary condylar chondrocytes (rPCCs) treated with SPRC (25, 50, or 100 μM) for 24 h, as evaluated by the CCK8 assay. (D) RT-qPCR analysis of matrix degradation-related genes (Mmp3, Mmp9, and Mmp13) and matrix synthesis-related genes (Col2a1 and Acan). (E-F) Western blot analysis of COX2, MMP3, and MMP9 protein expression levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: #p<0.05, ##p < 0.01, and ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the IL-1β group. “ns” indicates no significance
Fig. 6
Fig. 6
SPRC reduced condylar chondrocytes ECM catabolism in vitro. (A) Representative images of condylar chondrocytes stained with toluidine blue to assess extracellular matrix (ECM) integrity. (B) Immunofluorescence staining of chondrocytes showing DAPI-stained nuclei (blue), phalloidin-stained F-actin (green), and COL2A1 (red). (C) Cell viability of rat primary condylar chondrocytes (rPCCs) treated with SPRC (25, 50, or 100 μM) for 24 h, as evaluated by the CCK8 assay. (D) RT-qPCR analysis of matrix degradation-related genes (Mmp3, Mmp9, and Mmp13) and matrix synthesis-related genes (Col2a1 and Acan). (E-F) Western blot analysis of COX2, MMP3, and MMP9 protein expression levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: #p<0.05, ##p < 0.01, and ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the IL-1β group. “ns” indicates no significance
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References

    1. Cai W, Wu A, Lin Z, et al. S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling. Mol Med. 2025;31:128. 10.1186/s10020-025-01186-6. - PMC - PubMed

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