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Review
. 2025 Mar 1;28(3):171-173.
doi: 10.34172/aim.31231. Epub 2025 Mar 1.

Retro-orbital Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review

Tanju Kapagan  1 , Nilufer Bulut  1 , Mehmet Halıcı  2 , Gokmen Umut Erdem  1
Affiliations
Review

Retro-orbital Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review

Tanju Kapagan et al. Arch Iran Med. .

Abstract

Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC). We present a case of a 61-year-old male with ChRCC who exhibited unusual metastasis to the retro-orbital area, a site rarely affected by RCC. The patient experienced diplopia and proptosis, prompting treatment with sunitinib and palliative radiotherapy. Remarkably, rapid improvement in ocular symptoms was observed following radiotherapy. Despite this localized response, the patient's overall condition deteriorated, highlighting the aggressive nature of ChRCC. This case underscores the importance of considering ChRCC in metastatic presentations and the potential efficacy of local palliative interventions.

Keywords: Cancer; Chromophobe renal cell carcinoma; Palliative radiotherapy; Retro-orbital metastasis.

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Conflict of interest statement

Competing Interests

The authors declare that they have no conflict of interest.

Figures

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