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. 2025 Apr 29;4(4):CD016010.
doi: 10.1002/14651858.CD016010.

Multi-level factors affecting adolescent and youth engagement in HIV-research in low- and middle-income countries: a qualitative evidence synthesis

Carmen Späth  1   2 , Neetha Shagan Morar  3 , Anja van der Westhuizen  4 , Bey-Marrié Schmidt  1   2
Affiliations

Multi-level factors affecting adolescent and youth engagement in HIV-research in low- and middle-income countries: a qualitative evidence synthesis

Carmen Späth et al. Cochrane Database Syst Rev. .

Abstract

This is a protocol for a Cochrane Review (qualitative). The objectives are as follows: To explore the views and experiences of adolescents and youth who engaged with (i.e. were approached for participation) or participated in HIV research in low-and middle-income countries. To develop a logic model or visual representation that depicts the variety of factors affecting adolescent and youth engagement in HIV-related research, and how these factors potentially work together.

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Conflict of interest statement

CS received funding from the European and Developing Countries Clinical Trials Partnership (EDCTP2) programme, supported by the European Union and the Fondation Botnar.

BS received funding from the EDCTP2 programme, supported by the European Union and the Fondation Botnar.

NM: none known

AvDW: none known

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References

Additional references

Ames 2019
    1. Ames HM, Glenton C, Lewin S, Tamrat T, Akama E, Leon N. Clients' perceptions and experiences of targeted digital communication accessible via mobile devices for reproductive, maternal, newborn, child, and adolescent health: a qualitative evidence synthesis. Cochrane Database of Systematic Reviews 2019, Issue 10. Art. No: CD013447. [DOI: 10.1002/14651858.CD013447] - DOI - PMC - PubMed
APA 2024
    1. American Psychological Association (APA). APA Dictionary of Psychology: Factor. December 2024. Available at https://dictionary.apa.org/.
Bengough 2018
    1. Bengough T, Elm E, Heyvaert M, Hannes K. Factors that influence women’s engagement with breastfeeding support: a qualitative evidence synthesis. Cochrane Database of Systematic Reviews 2018, Issue 9. Art. No: CD013115. [DOI: 10.1002/14651858.CD013115] - DOI - PMC - PubMed
Benoot 2016
    1. Benoot C, Hannes K, Bilsen, J. The use of purposeful sampling in a qualitative evidence synthesis: a worked example on sexual adjustment to a cancer trajectory. BMC Medical Research Methodology 2016;16(21):1-12. [DOI: 10.1186/s12874-016-0114-6] - DOI - PMC - PubMed
CASP 2024
    1. CASP. CASP Qualitative Research Checklist. Available at https://casp-uk.net/casp-tools-checklists/qualitative-studies-checklist 2024.
Closson 2021
    1. Closson K, Lee L, Dietrich JJ, Eeksinska ME, Hornschuh S, Smith, et al. Gender and power dynamics of social relationships shape willingness to participate in biomedical HIV prevention research among South African adolescents and young adults. Frontiers in Reproductive Health 2021;3:639391. - PMC - PubMed
Covidence [Computer program]
    1. Covidence. Melbourne, Australia: Veritas Health Innovation, 2025. Available at https://covidence.org. [Available at: https://www.covidence.org]
Day 2020
    1. Day S, Kapogiannis BG, Shah SK, Wilson EC, Theodore DR, Donaldson FC, et al. Adolescent HIV research ethics in resource-constrained settings: low and middle-income country research consortium experience and scoping review. Lancet. HIV 2020;7(12):e844-52. - PMC - PubMed
DiClemente 2010
    1. DiClemente RJ, McDermott Sales J, Borek N. Barriers to adolescents' participation in HIV biomedical prevention research. Journal of Acquired Immune Deficiency Syndrome 2010;54(1):s12-7. [DOI: 10.1097/QAI.0b013e3181e1e2c0] - DOI - PMC - PubMed
Fox 2024
    1. Fox T, Shrestha S, Kuehn R, Taylor M. Community views on mass drug administration for soil-transmitted helminths: a qualitative evidence synthesis. Cochrane Database of Systematic Reviews 2024, Issue 1. Art. No: CD015794. [DOI: 10.1002/14651858.CD015794] - DOI
Glenton 2013
    1. Glenton C, Colvin C, Carlsen B, Swartz A, Lewin, S, et al. Barriers and facilitators to the implementation of lay health worker programmes to improve access to maternal and child health: qualitative evidence synthesis. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No: CD010414. [DOI: 10.1002/14651858.CD010414.pub2] - DOI - PMC - PubMed
Glenton 2023
    1. Glenton C, Bohren MA, Downe S, Paulsen EJ, Lewin S. Cochrane Qualitative Evidence Synthesis: protocol and review template. Version 1.4b. Cochrane Person Centred Care, Health Systems and Public Health and Cochrane Norway 2023. [DOI: 10.5281/zenodo.5101812] - DOI
Goldstein 2022
    1. Goldstein M, Archary J, Haberer, JE, Kuhns LM, Kurth A, et al. Systematic review of mHealth Interventions for adolescent and young adult HIV prevention and the adolescent HIV continuum of care in low to middle income countries. AIDS Behavior 2022;27(Suppl 1):94-115. [DOI: 10.1007/s10461-022-03840-0] - DOI - PMC - PubMed
Govender 2018
    1. Govender K, Masebo WG, Nyamaruze P, Cowden RG, Schunter BT, Bains A. HIV prevention in adolescents and young people in the Eastern and Southern African region: a review of key challenges impeding actions for an effective response. Open AIDS Journal 2018;12:53-67. - PMC - PubMed
Harkness 2021
    1. Harkness A, Rogers BG, Balise R, Mayo D, Weinstein ER, Safren SA, et al. Who aren't we reaching? Young sexual minority men's non participation in an HIV-prevention and mental health clinical trial. AIDS Behavior 2021;25(7):2195–209. - PMC - PubMed
Hendersen 2024
    1. Hendersen JT, Ramanadhan S, Kimport K, Foster AM, Paynter RA, Sheridan R, et al. The experiences and perspectives of abortion seekers who travel for care: a qualitative evidence synthesi. Cochrane Database of Systematic Reviews 2024, Issue 10. Art. No: CD015565. [DOI: 10.1002/14651858.CD015565] - DOI - PMC - PubMed
Jaspan 2008
    1. Jaspan HB, Soka NF, Strodem AE, Mathews C, Mark D, Flisher AJ, et al. Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa. Vaccine 2008;26(45):5679-83. - PMC - PubMed
Lewin 2018
    1. Lewin S, Booth A, Glenton C, Munthe-Kaas H, Rashidian A, Wainwright M, et al. Applying GRADE-CERQual to qualitative evidence synthesis findings: introduction to the series. Implemention Science 2018;13:2. [DOI: 10.1186/s13012-017-0688-3] - DOI - PMC - PubMed
Mabaso 2021
    1. Mabaso M, Maseko M, Sewpaul R, Naidoo I, Jooste S, Takatshana S. Trends and correlates of HIV prevalence among adolescents in South Africa: evidence from the 2008, 2012 and 2017 South African National HIV Prevalence, Incidence and Behaviour surveys. AIDS Research and Therapy 2021;18(1):1-8. [DOI: 10.1186/s12981-021-00422-3] - DOI - PMC - PubMed
Noyes 2018
    1. Noyes J, Booth A, Flemming K, Garside R, Harden A, Lewin S, et al. Cochrane Qualitative and Implementation Methods Group guidance series—paper 3: Methods for assessing methodological limitations, data extraction and synthesis, and confidence in synthesized qualitative findings. Journal of Clinical Epidemiology 2018;97(1):49-58. - PubMed
NVivo 2025 [Computer program]
    1. Nvivo. Version 15. Denver, Colorado, USA: Lumivero, 2025. Available at https://lumivero.com/products/nvivo/.
Page 2021
    1. Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. [DOI: 10.1136/bmj.n71] - DOI - PMC - PubMed
Patton 2002
    1. Patton MQ. Qualitative Research and Evaluation Methods. 3rd edition. Thousand Oaks, California: Sage Publications, 2002.
Pincock 2020
    1. Pincock K, Jones N. Challenging power dynamics and eliciting marginalized adolescent voices through qualitative methods. International Journal of Qualitative Methods 2020;19:1-11. [DOI: 10.1177/1609406920958895] - DOI
Sawyer 2018
    1. Sawyer SM, Azzopardi PS, Wickremarathne D, Patton GC. The age of adolescence. Lancet Child and Adolescent Health 2018;2(3):223-8. [DOI: 10.1016/S2352-4642(18)30022-1] - DOI - PubMed
Schmidt 2022a
    1. Schmidt BM, Späth C, Pinxteren M, Chi PC, Wiysonge CS, Oliver J, et al. Barriers and facilitators of and strategies for successful community engagement in infectious disease clinical trials in low- and middle-income countries. Cochrane Database of Systematic Reviews 2022, Issue 8. Art. No: MR000066. [DOI: 10.1002/14651858.MR000066] - DOI
Schmidt  2022b
    1. Schmidt BM, Cooper S, Klerings I, Head K, Sell K, Houghton C, et al. Health policymakers' views and experiences of knowledge translation approaches to facilitate evidence-informed decision-making: a qualitative evidence synthesis. Cochrane Database of Systematic Reviews 2022, Issue 10. Art. No: CD015346. [DOI: 10.1002/14651858.CD015346] - DOI
Shah 2020
    1. Shah SK, Essack Z, Byron K, Slack C, Reirden D, Rooyen H, et al. Adolescent barriers to HIV prevention research: are parental consent requirements the biggest obstacle? Journal of Adolescent Health 2020;67(4):495-501. [DOI: 10.1016/j.jadohealth] - DOI - PMC - PubMed
Thomas 2008
    1. Thomas J, Harden A. Methods for the thematic synthesis of qualitative research in systematic reviews. BMC Medical Research Methodology 2008;8(45):1-10. - PMC - PubMed
Truong 2022
    1. Truong H, Guze MA, Ouma D, Bushman D, Mocello AR, Kadede K, et al. Community-Based HIV testing for urban youth in Western Kenya. AIDS and Behavior 2022;26:814-21. - PMC - PubMed
UNICEF 2024
    1. United Nations Children's Fund (UNICEF). Adolescents and young people. https://www.unicef.org/bulgaria/en/adolescents-and-young-people (accessed 13 November 2024).
WHO 2024
    1. World Health Organization (WHO). Adolescent health. https://www.who.int/health-topics/adolescent-health (accessed 13 December 2024).
World Bank 2024
    1. World Bank. Low and middle-income. https://data.worldbank.org/country/XO (accessed 13 November 2024).

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