The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
- PMID: 40298430
- PMCID: PMC12081188
- DOI: 10.1158/0008-5472.CAN-24-1607
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Abstract
Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. In this study, we established the Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMM), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Meticulous curation and collaboration with data depositors produced a robust and comprehensive database, enhancing the fidelity of the genetic landscape it depicts. The LCAMGDB aligned 859 tumors from GEMMs with human lung cancer mutations, enabling comparative analysis and revealing a pressing need to broaden the diversity of genetic aberrations modeled in the GEMMs. To accompany this resource, a web application was developed that offers researchers intuitive tools for in-depth gene expression analysis. With standardized reprocessing of gene expression data, the LCAMGDB serves as a powerful platform for cross-study comparison and lays the groundwork for future research, aiming to bridge the gap between mouse models and human lung cancer for improved translational relevance. Significance: The Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB) provides a comprehensive and accessible resource for the research community to investigate lung cancer biology in mouse models.
©2025 American Association for Cancer Research.
Conflict of interest statement
The authors declare no potential conflicts of interest.
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- R01CA285336/National Cancer Institute (NCI)
- R01 CA244841/CA/NCI NIH HHS/United States
- R37 CA251629/CA/NCI NIH HHS/United States
- R01 CA272945/CA/NCI NIH HHS/United States
- SFB1430/Deutsche Forschungsgemeinschaft (DFG)
- PI21/00764/Instituto de Salud Carlos III (ISCIII)
- R01CA240317/National Cancer Institute (NCI)
- U01 AI156189/AI/NIAID NIH HHS/United States
- R35CA263816/National Cancer Institute (NCI)
- P50 CA070907/CA/NCI NIH HHS/United States
- U01CA213338/National Cancer Institute (NCI)
- R01 CA240317/CA/NCI NIH HHS/United States
- R01 CA285336/CA/NCI NIH HHS/United States
- R01CA212415/National Cancer Institute (NCI)
- R01DE030656/National Institute of Dental and Craniofacial Research (NIDR)
- R01GM141519/National Institute of General Medical Sciences (NIGMS)
- P50CA070907/National Cancer Institute (NCI)
- U24 CA213274/CA/NCI NIH HHS/United States
- R35 CA263816/CA/NCI NIH HHS/United States
- R01GM140012/National Institute of General Medical Sciences (NIGMS)
- Howard Hughes Medical Institute (HHMI)
- U24CA213274/National Cancer Institute (NCI)
- R01 DE030656/DE/NIDCR NIH HHS/United States
- U01CA249245/National Cancer Institute (NCI)
- U01 CA213338/CA/NCI NIH HHS/United States
- R01 CA271540/CA/NCI NIH HHS/United States
- R01CA272945/National Cancer Institute (NCI)
- R01 GM140012/GM/NIGMS NIH HHS/United States
- R37CA251629/National Cancer Institute (NCI)
- R01 CA212415/CA/NCI NIH HHS/United States
- P30 CA008748/CA/NCI NIH HHS/United States
- R35GM136375/National Institute of General Medical Sciences (NIGMS)
- R01CA244841/National Cancer Institute (NCI)
- R01 GM141519/GM/NIGMS NIH HHS/United States
- R35 CA220449/CA/NCI NIH HHS/United States
- GR4575/1-2/Deutsche Forschungsgemeinschaft (DFG)
- R01CA271540/National Cancer Institute (NCI)
- IRG-21-142-16/American Cancer Society (ACS)
- U01 CA249245/CA/NCI NIH HHS/United States
- R35 GM136375/GM/NIGMS NIH HHS/United States
- U01AI156189/National Institute of Allergy and Infectious Diseases (NIAID)
- P50 CA228944/CA/NCI NIH HHS/United States
- P50CA228944/National Cancer Institute (NCI)
- R35CA220449/National Cancer Institute (NCI)
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