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Review
. 2025 Apr 29;51(1):189.
doi: 10.1007/s00068-025-02866-y.

Biochemical markers of myocardial contusion after blunt chest trauma

Makhabbat Bekbossynova  1 , Murat Mukarov  2 , Perizat Kanabekova  3 , Zhanerke Shaktybek  2 , Madina Sugralimova  2 , Arman Batpen  4 , Anar Kozhakhmetova  4 , Zhumagul Sholdanova  2 , Aknur Zhanbolat  2
Affiliations
Review

Biochemical markers of myocardial contusion after blunt chest trauma

Makhabbat Bekbossynova et al. Eur J Trauma Emerg Surg. .

Abstract

One of the most common manifestations of cardiac injury because of trauma is myocardial contusion. Today, the blurred definition and wide range of nonspecific clinical presentations led to absence in consensus of diagnostic pathways and criteria. Currently, the marker of cardiac injury measured at clinical level is troponin and instrumental diagnostic tool is ECG. The patients with elevated troponin level after the chest trauma should be suspected to have myocardial contusion as cardiogenic shock or arrhythmia might take place as a complication. The release of DAMPs after the trauma has been observed as a part of inflammatory response to it. HMGB1 protein and histone levels were found to be elevated in patients with trauma and associated to recruit the inflammation. In this review the potential of these molecules to be used as diagnostic markers of myocardial contusion is discussed. Moreover, the obstacles for implementing DAMPS to clinical protocols and future research directions are included.

Keywords: DAMPs; HMGB1; Inflammation; Markers; Myocardial contusion.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Pathophysiology of Myocardial Contusion
Fig. 2
Fig. 2
Biomarkers Pathways
See this image and copyright information in PMC

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