Key advances in cardiac computed tomography: A review of the most relevant studies published in 2024 on coronary and structural heart disease

Pablo M Rubio¹, Hector M Garcia-Garcia², Agostina A Sanchez¹, Abdulhamied Alfaddagh³, Daniele Andreini⁴, Andrea Baggiano⁴, Arzu Canan⁵, Marcus Chen⁶, Benjamin J W Chow⁷, Anjali Chelliah⁸, Edoardo Conte⁹, Carlo N De Cecco¹⁰, Timothy Fairbairn¹¹, Maros Ferencik¹², Grudun Feuchtner¹³, Bernhard Föellmer¹⁴, Cristina Fuss¹⁵, Heidi Gransar¹⁶, Ashraf Hamdan¹⁷, B Kelly Han¹⁸, Sandina Jamieson⁷, Brian Ko¹⁹, Jonathan A Leipsic²⁰, Nidhi Madan²¹, Florian Michallek²², Saima Mushtaq⁴, Prashant Nagpal²³, Ming-Yen Ng²⁴, Edward Nicol²⁵, Hiroyuki Niinuma²⁶, Gianluca Pontone²⁷, Amir Pourmorteza¹⁰, Anna Reid²⁸, Jonathan R Weir-McCall²⁵, Seamus Whelton²⁹, Michelle Williams³⁰, Jeannie Yu³¹, Armin Arbab-Zadeh²⁹

Affiliations

¹ MedStar Washington Hospital Center, Washington DC, USA.
² MedStar Washington Hospital Center, Washington DC, USA. Electronic address: hector.m.garciagarcia@medstar.net.
³ Jabar AlAhmad Hospital, South Surra, Kuwait.
⁴ Centro Cardiologico Monzino IRCCS, Milan Italy.
⁵ UT Southwestern Medical Center, Dallas, TX, USA.
⁶ National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA.
⁷ University of Ottawa Heart Institute, Ottawa, Canada.
⁸ Morristown Medical Center, Morristown, NJ, USA; Columbia University Irving Medical Center, New York, USA.
⁹ Ospedale Galeazzi SpA, Milano, Italy.
¹⁰ Emory University, Atlanta, GA, USA.
¹¹ Liverpool Heart and Chest Hospital NHS Trust, Liverpool, United Kingdom.
¹² Oregon Health and Science University, Portland, OR, USA.
¹³ Medical University of Innsbruck, Innsbruck, Austria.
¹⁴ Charite Universitatsmedizin Berlin, Berlin, Germany.
¹⁵ Yale School of Medicine, USA.
¹⁶ Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹⁷ Rabin Medical Center, Petah Tikva, Israel and Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
¹⁸ University of Utah, Salt Lake City, UT, USA.
¹⁹ Victorian Heart Hospital, Clayton, Australia.
²⁰ University of British Columbia, Vancouver, British Columbia, Canada.
²¹ Methodist Health System, Omaha, NE, USA.
²² Mie University Graduate School of Medicine, Tsu, Japan.
²³ Department of Radiology, University of Wisconsin and School of Public Health, Madison, WI, USA.
²⁴ School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
²⁵ Royal Brompton Hospital, Guys and St Thomas' NHS Trust, London, United Kingdom; King's College, Londonm, United Kingdom.
²⁶ Saint Luke's International Hospital, Tokyo, Japan.
²⁷ Centro Cardiologico Monzino IRCCS, Milan Italy; University of Milan, Milan, Italy.
²⁸ The University of Manchester, Manchester, United Kingdom.
²⁹ Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³⁰ The University of Edinburgh, Edinburgh, United Kingdom.
³¹ VA Long Beach Healthcare System, Long Beach, CA, USA.

PMID: 40300917
DOI: 10.1016/j.jcct.2025.04.008

Review

Key advances in cardiac computed tomography: A review of the most relevant studies published in 2024 on coronary and structural heart disease

Pablo M Rubio et al. J Cardiovasc Comput Tomogr. 2025 May-Jun.

. 2025 May-Jun;19(3):291-298.

doi: 10.1016/j.jcct.2025.04.008. Epub 2025 Apr 22.

Authors

Affiliations

¹ MedStar Washington Hospital Center, Washington DC, USA.
² MedStar Washington Hospital Center, Washington DC, USA. Electronic address: hector.m.garciagarcia@medstar.net.
³ Jabar AlAhmad Hospital, South Surra, Kuwait.
⁴ Centro Cardiologico Monzino IRCCS, Milan Italy.
⁵ UT Southwestern Medical Center, Dallas, TX, USA.
⁶ National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA.
⁷ University of Ottawa Heart Institute, Ottawa, Canada.
⁸ Morristown Medical Center, Morristown, NJ, USA; Columbia University Irving Medical Center, New York, USA.
⁹ Ospedale Galeazzi SpA, Milano, Italy.
¹⁰ Emory University, Atlanta, GA, USA.
¹¹ Liverpool Heart and Chest Hospital NHS Trust, Liverpool, United Kingdom.
¹² Oregon Health and Science University, Portland, OR, USA.
¹³ Medical University of Innsbruck, Innsbruck, Austria.
¹⁴ Charite Universitatsmedizin Berlin, Berlin, Germany.
¹⁵ Yale School of Medicine, USA.
¹⁶ Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹⁷ Rabin Medical Center, Petah Tikva, Israel and Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
¹⁸ University of Utah, Salt Lake City, UT, USA.
¹⁹ Victorian Heart Hospital, Clayton, Australia.
²⁰ University of British Columbia, Vancouver, British Columbia, Canada.
²¹ Methodist Health System, Omaha, NE, USA.
²² Mie University Graduate School of Medicine, Tsu, Japan.
²³ Department of Radiology, University of Wisconsin and School of Public Health, Madison, WI, USA.
²⁴ School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
²⁵ Royal Brompton Hospital, Guys and St Thomas' NHS Trust, London, United Kingdom; King's College, Londonm, United Kingdom.
²⁶ Saint Luke's International Hospital, Tokyo, Japan.
²⁷ Centro Cardiologico Monzino IRCCS, Milan Italy; University of Milan, Milan, Italy.
²⁸ The University of Manchester, Manchester, United Kingdom.
²⁹ Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³⁰ The University of Edinburgh, Edinburgh, United Kingdom.
³¹ VA Long Beach Healthcare System, Long Beach, CA, USA.

PMID: 40300917
DOI: 10.1016/j.jcct.2025.04.008

Abstract

This review highlights the most relevant and influential studies on coronary and structural cardiac computed tomography published in 2024. The clinical utility of coronary CT angiography (CCTA) continues to expand, supported by advancements in quantitative plaque analysis, functional assessment through FFR-CT, and the integration of artificial intelligence (AI). Photon-counting CT has emerged as a promising technology for improving image quality and diagnostic accuracy. In structural heart disease, CCT has become an indispensable tool for procedural planning and risk stratification across multiple valvular interventions. Moreover, CT-derived extracellular volume (CT-ECV) and AI-based assessment of myocardial mass and epicardial adipose tissue are gaining traction as novel prognostic biomarkers. These developments reflect the growing adoption of CCT in both clinical practice and cardiovascular research, underscoring its role as a cornerstone modality in modern cardiology.

Keywords: Artificial intelligence; Cardiac computed tomography; Coronary artery disease; Quantitative plaque analysis; Structural heart disease.

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Conflict of interest statement

Declaration of competing interest Hector M. Garcia-Garcia is a consultant for Boston Scientific, Abbott, Medis. His institution receives research grants from: Boston Scientific, Abbott, Chiesi, Biotronik, Cordis, Medis, Phillips. Carlo DeCecco reports Research grant/consultant Siemens, Cleerly, Elucid. Cristina Fuss is a consultant for HeartFlow. Maros Ferencik reports consulting fees from Cleerly, HeartFlow, Elucid, and BioMarin, advisory board of Cleerly and Elucid, and stock options Elucid. Jonathan A. Leipsic is a consultant for Circle CVI and Heartflow. Prashant Nagpal reports consulting fees from GE Healthcare, WCG Clinical and grant support from Canon Medical and stock ownership of Moderna. Ming-Yen Ng has received speaker fees from Circle CVI, GE Healthcare, Boerhinger Ingelheim, Bayer and grant support from Bayer, GE Healthcare, TeraRecon. Florian Michallek’s institution receives endowment support from Siemens Japan. Edward Nicol is a member of Caristo Diagnostics Scientific Advisor Board. Benjamin Chow receives research support from TD Bank and Artrya. He is a consultant for Artrya and has an equity interest in: Artrya, Becton Dickson and Co, McKesson, Proctor and Gamble. Armin Arbab-Zadeh receives research support from Canon Medical Systems and Royalties from Nature-Springer. All other authors have no relevant disclosures.

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Key advances in cardiac computed tomography: A review of the most relevant studies published in 2024 on coronary and structural heart disease

Affiliations

Key advances in cardiac computed tomography: A review of the most relevant studies published in 2024 on coronary and structural heart disease

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical