Applications of Fibroblast Activation Protein Inhibitor-PET in Interventional Oncology

Abstract

Molecular imaging-guided techniques increase precision in surgical procedure and reduce postinterventional morbidity. Fibroblast activation protein (FAP) ligands may contribute to the superior preoperative assessment compared with conventional radionuclides due to its higher sensitivity and tumor delineation in epithelial malignancies. Wide spectrum of currently available FAP ligands including diagnostic and therapeutic emitters allows a flexibility regarding the optimal choice for individual need. Moreover, newly introduced hybrid tracers with fluorescence-based FAP probes enrich this spectrum by providing intraoperative FAP-targeting without radiation exposure. Thus, the use of FAP ligands in interventional oncology has great promise in improving the efficiency of local-interventional surgery.

Keywords: FAPI; Fibroblast activation protein; Interventional oncology; PET; Theranostics.